Page 69 - CIBERSAM-2015-eng

Research Groups
Most relevant scientific articles
raPado-castro M., Pazos a., Fananas l., Bernardo M., ayuso-Mateos J.l., leza J.c. et al. Building up careers in translational neuroscience and mental health research: Education and training in the Centre for Biomedical Re- search in Mental Health. Revista de Psiquiatria y Salud Mental. 2015;8(2):65-74.
erdozaIn a.M., ruBIo M., ValdIzan e.M., Pazos a., JaVIer Meana J., Fernández-ruIz J. et al. The endocannabinoid system is altered in the post-mortem prefrontal cortex of
herrero a., PInto a., colon-Bolea P., casar B., Jones M., aGudo-IBanez l. et al. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Path- way Oncogenes. Cancer Cell. 2015;28(2):170-182.
curIel-olMo s, García-castaño a, VIdal r, PIsonero h, Varela I, león-castIllo a et al. Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signa- tures.Oncotarget. 2015.
alcoholic subjects. Addiction Biology. 2015;20(4):773-783.
Ferres-coy a., GaloFre M., PIlar-cuellar F., VIdal r., Paz V., ruIz-Bronchal e. et al. Therapeutic antidepres- sant potential of a conjugated siRNA silencing the seroto- nin transporter after intranasal administration. Molecular Psychiatry. 2015.
Highlights
Our group has continued the research on the neuro- plasticity mechanisms underlying the pathogenesis of major depression (Wnt/β-catenin and mTOR), as well as the identification of new potential therapeu- tic targets for the treatment of depression (5-HT4 receptor and the endocannabinoid system). As result of the latter goal, a doctoral thesis entitled “Potential of cannabidiol for rapid antidepressant therapy: behavioral, neurochemical, molecular and cellular evidences. Involvement of serotonergic and glutamatergic systems”, has been presented by Dr. Raquel Linge. We have also published the related article “Cannabidiol induces rapid-acting antidepres- sant-like effects and enhances cortical 5-HT/gluta- mate neurotransmission: role of 5-HT1A receptors”, in Neuropharmacology (first decile), and a second article has been submitted and is already under re- view in the same journal.
Regarding academic training, our group continues coordinating the “Máster Interuniversitario de Ini- ciación a la Investigación en Salud Mental”. Addi- tionally, we are currently supervising two doctoral theses.
We have also participated in a collaboration agree- ment with the pharmaceutical company Servier, evaluating potential antidepressant drugs in behav- ioral and neurochemical paradigms.
Institution: Universidad de Cantabria · Contact: Facultad de Medicina. Inst. de Biomedicina y Biotecnología de Cantabria · C/ Albert Einstein, 22. 39011 Santander · Tel.: 942 201 985 · E.mail: [email protected] Website: http://www.unican.es/ibbtec/investigacion/Accion-de-farmacos-sobre-SNC.htm
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