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leaD reSearcHer
Perona Abellón, Rosario
Agencia Estatal Consejo Superior de Investigaciones Científicas
Instituto de Investigaciones Biomédicas Alberto Sols
C/ Arturo Duperier 4 28029 Madrid
(+34) 91 585 44 63 [email protected] group website
GROUP MEMBERS
Staff members: Manguan García, Cristina
Contratados a cargo de proyecto: Rodríguez Centeno, Javier Associated members: Sánchez Pérez, Isabel | Sastre Garzón, Leandro
Main lines of research
• Application of a rescue therapy in diseases associated with telomerase activity deficiency. Signalling pathways active in dyskeratosis congenita in response to DNA damage. Improve the activity of nanoparticles and lentiviral vectors for gene therapy.
• Development of a therapy base in the GSE24.2 peptide fro the treatment of short telomeres associated diseases, increase oxidative stress and geentic instability.
• Genetic diagnosis of DC y study of telomere lenght in patients of DC and idiophatic pulmonary fibrosis. Study of models of idiopathic pulmonary fibrosis using stem cells and KO mouse models for DUSP1.
• Investigation about the activity of GSE4 for the treatment of idiophatic pulmonary fibrosis.
• Use of GSE4 for the treatment of ataxia telangiectasia.
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PROGRAMMES
Inherited Cancer, Haematological and Dermatological Diseases
