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leaD reSearcHer
Botella Cubells, Luisa María
Agencia E. Consejo Superior de Investigaciones Científicas Centro de Investigaciones Biológicas
Ramiro de Maeztu, 9 28040 Madrid
(+34) 918373112
group website
GROUP MEMBERS
Staff members: Albiñana Díaz, Virginia | Ruiz Llorente, Lidia
Associated members: Bernabéu, Carmelo | Gallardo Vara, Eunate | Langa Poza, Carmen | Morales Angulo, Carmelo | Zarrabeitia Puente, Roberto
Main lines of research
• Studies of expression, function and structure of endoglin and its relevance in hereditary hemorrhagic telangiectasia and other pathologies such as preeclampsia.
• Genetic and cellular studies on the Spanish population with hereditary hemorrhagic telangiectasia.
• Molecular diagnostics and characterization of pathogenic mechanisms of hereditary hemorrhagic
telangiectasia in the TGF-beta signaling pathway.
• Cellular and animal models for studying the function of endoglin and ALK1 in physiopathology.
• New therapies for hemangioblastomas and carcinomas from the von Hippel Lindau (VHL) disease,
produced by constitutive expression of hypoxia inducible factor (HIF).
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PROGRAMMES
Genetic Medicine
