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structure (i.e. eye or dLGN, caused by mutations in specific transcription factors) affect the entire system. On the other hand, we have followed our interest in Secreted Frizzled Related Proteins (Sfrps) that are multifunctional regulator of Wnt and metalloproteases activity. We are actively working on the idea that Sfrp1 might be one of the multiple and yet unclear triggers of Alzheimer’s disease. We are using multiple genetic approaches in mice and human tissue to test this hypothesis.
Most relevant scientific articles
• Morales A.V., Espeso-Gil S., Ocana I., Nieto-Lopez F., Calleja E., Bovolenta P. et al. FGF signaling enhances a sonic hedgehog negative feedback loop at the initiation of spinal cord ventral patterning. Developmental Neurobiology. 2016.
Hightlights
PROJECTS
• Control of cell-cell communication: from neural development to neurodegeneration. MINECO
(BFU2013-43213-P), 2014-2016, 508.200 €. PRINCIPAL INVESTIGATOR: Paola Bovolenta y Pilar Esteve.
• Genereting neuronal diversity. (RedDevNeural), MINECO (BFU2014-55738-REDT), 01/12/2014 a
30/11/2016, 32.000 €. INVESTIGADOR PRINCIPAL: Paola Bovolenta (10 groups).
• Understanding and reprogramming developmental visual disorders: from anophthalmia to cortical
impairments (ImprovVision), ERA-NET Neuron II, 2015-2018, 149.000 € por el grupo. Coordinator: Paola
Bovolenta (5 groups).
• Understanding Sfrp1 activity as a novel component implicated in the pathogenesis of alzheimer’s
disease. Fundación Tatiana Pérez de Guzmán el Bueno, 2015-2017, 108.900 €. PRINCIPAL INVESTIGATOR: Paola Bovolenta.
COEDITOR OF THE FOLLOWING BOOK
• Organogenetic gene networks. Castelli-Gair Hombria, J and Bovolenta P. editors, Springer.
BOOK CHAPTERS
• Castelli-Gair Hombria, J and Bovolenta P (2016) Models for studying Organogenetic gene networks in
the 21st century. In: Organogenetic gene networks. Castelli-Gair Hombria, J and Bovolenta P. editors,
Springer. pp 1-7.
• Cavodeassi, F., Moreno-Marmol, T., Henandez-Bejarano, M and Bovolenta, P. (2016) Principles of
early vertebrate forebrain formation. In: Organogenetic gene networks. Castelli-Gair Hombria, J and Bovolenta P. editors, Springer. pp 299-317.
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