Page 45 - MemoriaCIBER-2017ENG

Scienti c Programmes
Myocardial injury and its consequences
Coordinators: Francisco Fernandez-Avilés / Juan Cinca
Over this rst year in our career, Programme 1, intended to understand and treat myocardial injury and its associated clinical consequences, has obtained some signi cant results from transfer in cooperation with the cardiovascular research network
In the line of scar-forming and structural and electrophysiological remodelling, we should stress the article entitled Long-Term Potassium Monitoring and Dynamics in Heart Failure and Risk of Mortality pub- lished in Circulation in which three CIBERCV groups give evidence vouching for the relevance of potassi- um levels in the prediction of the risk of death in heart failure Another major milestone for the CIBERCV was the worldwide coordination of the Global position paper on cardiovascular regenerative medicine published in European Heart Journal and in which the foundations are laid for translational research in cardiovascular regenerative medicine In the area of basic research into mechanisms the study entitled “Tbx20 controls the expression of the KCNH2 gene and of hERG channels” is worthy of mention This was published in the PNAS journal and coordinated by Dr Tamargo and examines the major role of Tbx20 in long QT syndromes
In the line of genetically-caused myocardial injury we should highlight the work entitled “Direct oral anti- coagulants in patients with hypertrophic cardiomyopathy and atrial brillation” published in Int J Cardiology and in which four Groups from the programme took part In this it proved that direct-action anticoagu- lants are safe and just as e ective as vitamin K-antagonists in patients with Hypertrophic cardiomyopa- thy (HCM) We must also mention the work entitled Additional value of screening for minor genes and copy number variants in hypertrophic cardiomyopathy, directed by Dr Brugada’s group and published in PLoS One, in which four groups from the programme took part Another important achievement in this direc- tion was obtaining the multicentre project on Etiological diagnosis of advanced conduction disorders which will enable laying the genetic foundations of conduction disorders in young subjects requiring a pacemaker implant
In the line of research into heart failure, thanks to the transfer performed with the Multicentre Register in Research in Heart Failure of Spain (i e REDISCOR I and II, and III starting now), one should emphasise three studies intended to improve clinical practice: (1) Nutritional status is related to heart failure severity and hospital readmissions in acute heart failure, (2) Mid-range left ventricular ejection fraction: Clinical pro- le and cause of death in ambulatory patients with chronic heart failure and (3) Proposal of a novel clinical score to predict heart failure incidence in long-term survivors of acute coronary syndromes, published in the International Journal of Cardiology in which the close cooperation between members in the line was vital In this approach a major e ort was also made in identifying Clinical outcomes of temporary mechanical circulatory support as a direct bridge to heart transplantation: a nationwide Spanish registry coordinated by Dr Crespo and published in Eur J Heart Failure