Page 70 - MemoriaCIBER-2017ENG

Gastrointestinal physiopathology: in ammatory bowel disease and motility disorders
Coordinador: Pere Clavé Civit
Clinical-Scienti c relevance of the subjects in the programme
This programme includes digestive diseases of great prevalence and impact on the health and quality of the population’s life, structured in three overall lines: a) Oesophageal–gastroduodenal pathology; b) In ammatory bowel syndrome; and c) Neuro-gastroenterology, alterations of digestive motility and func- tional disorders Knowledge of the physiopathology, diagnosis, epidemiology, prevention and treatment of these diseases is furthered by means of cooperative and multidisciplinary research among investigators with clinical, basic and epidemiological orientation At the same time, a line of cooperation was created between basic researchers by means of a strategic IntraCIBEREHD action which involves most of the groups During 2017 the merger of two research groups was consolidated, one group joined, and the group leaders were replaced
a) Oesophageal-gastroduodenal pathology.
The innovations in 2017 in this area focus on the development of new ultrafast tests of in- fection by Helicobacter pylori and on the publication of di erent guides and consensus on the strategies for eradicating infection and of di erent studies and phase IV clinical tests compar- ing the e ectiveness and security of many di erent antibiotic combinations The study of the adverse e ects of non-steroidal anti-in ammatory drugs in peptic disease and its complica- tions (mainly digestive haemorrhage) also occupies a relevant place in this line of research, as well as new studies on oesophageal-gastric cancer
b) In ammatory bowel disease.
This is the most productive line in this area and the one to which most human and material resources are allocated The research is directed at the primary causes of immune dysfunc- tion and recognition of genetic and environmental determinants conditioning the phenotypic development of each IBD The results for 2017 are very relevant as regards the treatment of perianal Crohn’s disease with stem cells, the publication of many studies and clinical trials comparing the e ectiveness and security of di erent immune-modulatory treatments in dif- ferent phases of the disease (active/remission) and the appearance of studies which evaluate the complications of di erent types (nutritional, quality of life) and optimum clinical handling This line also includes research projects connected with celiac disease, an area in which a new group is joining
c) Neuro-gastroenterology, alterations of digestive motility and functional digestive disorders.
2017 was a signi cant year for the study of disorders such as IBS, with a prevalence of 15% of the general population, or such as Oropharyngeal Dysphagia (OD), which a ects 50% of the patients who have su ered from a stroke, neurodegenerative diseases and frail elderly per- sons The 2017 studies focus on the mechanisms for CNS dysfunction associated with these pathologies, the role of the diet in their physiopathology and treatment, on the mechanisms for abdominal distension and handling of intestinal gas and on the role of intestinal perme- ability On a training level one should stress the World Dysphagia Summit held in Barcelona with the cooperation of CIBEREHD
70 CIBER ANNUAL REPORT 2017