Page 75 - MemoriaCIBER-2017ENG

Platforms
Bioinformatics Liver Diseases
Coordinator: Juanjo Lozano Salvatella
The Bioinformatics platform is taking an active part in the operation of this CIBER, as is shown by the 11 publications issued as a result of its support during 2017 The most relevant publication is connect- ed with the mechanism for action of immunosuppressants in the eld of liver transplants, in which a project from the “Marató”, led by our group, in the framework of an international collaboration scheme, was published:
• Whitehouse G, Gray E, Mastoridis S, Merritt E, Kodela E, Yang JHM, Danger R, Mairal M, Christakoudi S, Lozano JJ, Macdougall IC, Tree TIM, Sanchez-Fueyo A, Martinez-Llordella M IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors Proc Natl Acad Sci U S A 2017 Jul 3;114(27):7083-7088 2017
Cooperation with CIBEREHD Groups continues to generate relevant publications
In ammation in the Liver Disease Area:
• Rius B, Duran-Güell M, Flores-Costa R, López-Vicario C, Lopategi A, Alcaraz-Quiles J, Casulleras M, Lozano JJ, Titos E, Clària J The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress FASEB J 2017 Dec;31(12):5384-5398
In ammatory Bowel Disease Area:
• Planell N, Masamunt MC, Leal RF, Rodríguez L, Esteller M, Lozano JJ, Ramírez A, Ayrizono MLS, Coy CSR, Alfaro I, Ordás I, Visvanathan S, Ricart E, Guardiola J, Panés J, Salas A J Crohns Colitis 2017 Oct 27;11(11):1335-1346
It should be stressed that a project nancing Meritxell Gironella from the Gastrointestinal and Pancre- atic Oncology Group as Principal Investigator, forming the platform as investigating team, whose title is PI17/01003 “Evaluation of the prognostic capacity and of the functional role of microRNA candidates in pancreatic ductal adenocarcinoma” will be nanced by the Instituto de Salud Carlos III in the next three years
Finally, in respect of the bioinformatic tool (MIRComb), which has been developed in our group to study interactions between microRNA and their target genes, the investigator in charge Maria Vila Casadesús got the highest mark in her doctoral thesis: Design of bioinformatic tools for integrative analysis of miR- NA-mRNA interactome applied to digestive cancers