Page 42 - MemoriaCIBER-2018ENG

42
Scientific programmes
Myocardial damage and its consequences
In the line of genetically caused myocardial damage we should highlight the work entitled “Dilated Cardiomyopathy Due to BLC2- Associated Athanogene 3 (BAG3) Mutations”, published in the Journal of the American
Coordinators:
Francisco Fernandez-Avilés Juan Cinca
In the second year’s work done in programme
1, intended to understand and treat myocardial damage and its associated clinical consequences, some of the major targets set in the scientific management plan of CIBERCV have been achieved. This text attempts to give some examples of the accomplishments representing the entire work done by the programme:
In the line of structural and electrophysiological remodelling and scar-formation, it is important to stress the start of the “AdiFLAP Trial”, financed by the Instituto de Salud
Carlos III and in which the therapy of adipose graft transposition procedure (AGTP) will be validated to reduce the size of the post-infarction myocardial scar. This is a multi-centre project taking advantage of a structure like that of the CIBERCV to transfer a basic research study carried out by Dr Antoni Bayes-Genís’ group to clinical practice.
College of Cardiology, in which over ten CIBERCV institutions have taken part. In this it was proven that dilated cardiomyopathy caused by mutations in gene BAG3 is characterised by a high penetration in carriers over 40 years of age and with a high risk of progressive heart failure, showing the importance of including this gene in the panels of genetic tests of hypertrophic cardiomyopathy.
In the line of research into heart failure, we should stress getting under way the prospective registry (Redinscor III) of patients with debut heart failure in which eleven CIBERCV groups are taking part and in which nearly 200 patients have been included in only three months from starting inclusion. This study involves taking
a blood sample and clinical follow-up of all the patients for 3, 6 and 12 months and will be of vital importance to be able to reveal the causes and evolution of this major pathology. Some important steps forward in knowledge are
being made thanks to prior registries Redicor
I and II, such as for example the study entitled “Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry” published in 2018 in the Clinical Cardiology journal.
CIBERCV | ANNUAL REPORT 2018