Page 120 - MemoriaCIBER2019-ENG

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CIBER Annual report 2019
have on health, its social determinants and inequalities in health in Spain and its Autonomous Communities. Both the indicator directory and the data will be periodically reviewed and updated. Thus, it becomes a highly useful tool for both public health professionals and the general public. The atlas can be consulted at the following website https://www.osman.es/atlas/
P5. Epidemiology and prevention in environmental and occupational health
Coordinator: Mariana Fátima Fernández Cabrera* (*Until November the coordinator was Dr. Adonina Tardón)
Group led by Eulalia Martí Puig (PI): detection of patterns of germline genetic variants in cancer patients (Pancan- cer Analysis of Whole Genomes study), and identification of variants with effect on susceptibility to disease (Nature, 578 (7793), 82-93 2020). Co-leadership of the PI17 / 01935 project: Identification of molecular QTLs and their interac- tions with environmental factors in children: a study of molecular endophenotypes from the HELIX project. .
Group led by Nicolás Olea Serrano (PI): They have shown that: i) neonatal ICU medical devices involve exposure to Bisphenol A (BPA) and parabens in very low birth weight infants (Iribarne-Durán et al. EHP 2019; 127 (11): 117004 ); ii) general / occupational population exposed to BPA by thermal paper (Molina-Molina et al. Environ Res 2019; 170: 406-15); and iii) exposure to GAP and parabens in children’s clothing <3 years (Freire et al. Environ Int 2019; 127: 592- 600). INMA-Granada follow-up (15-17 years) and exposure to non-persistent pesticides in the entire INMA cohort. Leadership WP14 (Effect Biomarkers) within HBM4EU / H2020.
Group led by Coral Sanfeliu Pujol (PI) and CIBERFES demonstrate improvements in the memory of amateur rugby players (45-65 years old) compared to subjects with low physical activity, and identify biomarkers of the effect of chronic exercise in blood: i) decrease in lipid peroxidation (malondialdehyde), ii) adjustment of pro-cognitive factors (BDNF and Cathepsin B), iii) increased expression of rejuvenation and neuroprotection genes (SIRT1, SIRT3) and an- tioxidants (CAT, SOD1) and decrease of pro-inflammatory cytokines (IL1B) (de la Rosa et al., Sci Rep 2019; 9: 3337; Corpas et al., Front Aging Neurosci. 2019; 11: 352).
Group led by Jordi Sunyer Deu (PI): they have discovered that early exposure to air pollution is related to mild thyroid dysfunction during pregnancy and impairment of various cognitive functions, including working memory, attention function, memory, verbal and general cognition. Furthermore, prenatal exposure to air pollution is associa- ted with a decrease in corpus callosum volume and, in turn, with an increased risk of hyperactivity problems.
Group led by Adonina Tardón García (PI): they assess the influence of genetic determinants on the incidence and evolution of lung cancer and the clinical utility of telomere length as a prognosis in non-small cells. INMA-Asturias (11 years): they have studied pre- and postnatal exposure to POPs with obesity and metabolic syndrome, evaluating RR and main adipokines.
Group led by Carmen Iñiguez Hernández (PI): participation and obtainment of projects: “Cervico-vaginal mi- crobiota and human papillomavirus (HPVs) -related dysplasias in perimenopause: A pilot study” / IDEAS SEMI- LLA-AECC; “MercuryGenII-Genetic susceptibility to methylmercury”/Karolinska Institutet-Formas 2016-504; “Fine Particulate Matter, Fetal Growth & Neurodevelopment: Examining Critical Windows of Susceptibility” / NIEHS # 1R01ES028842-01A1. Relevant publications: Soler-Blasco et al. Environ Int 2019; 130: 104835; Costa et al. Environ Int 2019; 130: 104830.
Group led by Francisco Bolumar Montrull (PI): in INMA, high doses of folic acid in pregnancy are associated with an increased risk of low birth weight; and the consumption of sugary drinks, a higher intake of trans fatty acids and a lower adherence to the Mediterranean diet, with a higher risk of childhood obesity. In PREDIMED-PLUS, they observe that the Mediterranean low-calorie diet is associated with weight loss at the 1st and 2nd year of follow-up with favo- rable evolution of cardiovascular risk markers in those treated (18 publications -Diabetes Care and JAMA-).
Group led by Ricardo Marcos Dauder (PI): collaboration with the group led by Emmanouil Kogevinas evaluating genetic damage associated with exposure to DBPs in swimming pools (Environ Int, 131: 104988, 2019). They investi- gate genotoxicity markers as risk indicators in patients with bladder cancer (Environ Mol Mutagen, 60: 168-173, 2019)