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Most relevant • sIlbeRnaGel G, ChaPMan Mj, GenseR b, klebeR Me, FauleR G, sChaRnaGl h et al.. High intes-
tinal cholesterol absorption is associated with cardiovascular disease and risk alleles
scientific
in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-
articles
analysis.J Am Coll Cardiol. 2013 Jul 23;62(4):291-9.

• s F, G-R C, R-M e, G-F e, a MC, C n
oRIGueRutIéRRezePIsoubIoaRtínaRCíauenteslMaRazoloMoet
al.. Metabolically healthy but obese, a matter of time? Findings from the prospective
Pizarra study.J Clin Endocrinol Metab. 2013 Jun;98(6):2318-25.

• M-n GM, C-M R, R-M G, G-z jM, C Fj,
aRtínúñezabReRauleRoojoaRtínezóMezuMaqueRohaVes
de MaRCo G et al.. Polymorphisms in the SCD1 gene are associated with indices of
stearoyl CoA desaturase activity and obesity: a prospective study.Mol Nutr Food Res.

2013 Dec;57(12):2177-84.

• Rojo-MaRtínez G, soRIGueR F, ColoMo n, Calle a, Goday a, boRdIú e et al.. Factors deter-

mining high-sensitivity C-reactive protein values in the Spanish population. Di@bet.
es study.Eur J Clin Invest. 2013 Jan;43(1):1-10.
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• G-R C, R-M G, s F, G-F e, V j, V ja
utIRRezePIsoojoaRtínezoRIGueRaRCíauentesendRellázquez
et al.. Factors affecting levels of urinary albumin excretion in the general population
of Spain: the [email protected] study.Clin Sci (Lond). 2013 Feb;124(4):269-77.

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• Study of insulin resistance and diabetes. The aim is the early detection of insulin-
Highlights
resistance, identifying early markers and risk and inflammatory factors linked to
this condition. Identification of the correlation between the levels of C-reactive

protein and the incidence of type 2 diabetes and identification of the correlation

between levels of homocysteine and diabetic neuropathy.

• Detection of genetic alterations (mutations or polymorphisms) involved in the
development of complex diseases with high cardiovascular risk focused on genes

related to the mitochondrial respiratory chain, oxidative stress, lipid metabolism

and diabetes. We have studied the association of 65 polymorphisms found in 25
genes of the mitochondrial respiratory chain. We have identified several poly-

morphisms associated with significant risk of developing obesity and metabolic

syndrome.

• Diagnosis, preventionand treatment of diabetic foot. Confirmation of our previ-
ous results connecting plasma homocysteine levels and risk for diabetic foot

ulceration

• Study of autosomal dominant hypercholesterolemias and familial combined hy-

perlipidemia. An analysis of inflammation markers has been performed, as well
as a comprehensive biochemical profile and a collection of clinical and genetic

characteristics.

• Effect of postprandial lipidemia on cardiovascular system, mainly on lipid profile,
13
inflammatory markers and oxidative stress and the response of circulanting cells 20
to stress caused by hyperlipidemia. Studies of oral lipid overload in obese dia- T
OR
betic patients have been carried out to study cell response to fatty acid delivery. P
RE
Expression of all genes present in the lymphomonocytes of these patients has L
been examined comparing with control subjects and the results are currently A
NU
being analyzed.
N
A
• Genetic factors involved in the regulation of Body Mass Index (BMI), waist cir- M /
E
cumference and obesity develpment. Study of oxidative stress and other aspects D
of metabolism as factors able to modulate development of obesity. Levels of ER
B
certain free radicals and oxidative stress regulate metabolism and energy ho- CI

meostasis.
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