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Highlights
In 2013, we dedicated special efforts to the analysis of data generated by the
European MetaHIT project, which obtained novel information about the gut mi-

crobial communities, not only regarding diversity, but also providing a novel view
of genetic potential and functional networks in the community. These tasks impli-

cated a special effort in developing bioinformatic tools for the analysis of massive

datasets, and turned in a successful outcome in terms of publications with a high
impact factor.

Our collaboration with the pharma industry aimed at developing novel drugs able

to stimulate proliferation of T regulatory cells in human intestinal mucosa. Our
organ-culture studies with human intestinal tissues have provided encouraging

results. Such drug could become a powerful treatment for immuno-inflammatory

disorders.

Our membership to the Guidelines Committee of the World Gastroenterology Or-
ganization has resulted this year in an important contribution to the production of

a new guideline of common digestive disorders (WGO practice guideline of 2013)

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