Page 102 - MemoriaEHD-Eng

RESEARCH GROUPS

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PROGRAMME:
G0066
Gastrointestinal
Inflammation and Motility

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Group Members
Lead Researcher

Lanas Arbeola, Ángel
STAFF MEMBERS
Arechavaleta Tabuenca, Samanta P.

Carrera Lasfuentes, Patricia
Contact:
Jimenez Molinos, M Pilar

Dpto. Aparato Digestivo.
Hospital Clinico Universitario Lozano Blesa. ASSOCIATED MEMBERS
Arroyo Villarino, Ma Teresa
Avda. San Juan Bosco 15. 50009 Zaragoza. · Phone: (+34) 976 765 786
E.mail: [email protected] · http://www.ciberisciii.es/grupo?id=16107
Benito Ruesca, Rafael
Casado Arroyo, Ruben

Ferrandez Arenas, Angel
Garca Gonzlez, Ma Asuncin Main lines of research

Gomolln Garca, Fernando DISEASES OF THE DIGESTIVE TRACT ASSOCIATED WITH ACID INHIBITION OF COX

Ortego Fdez. de Retana, Fco. Javier OR H. PYLORI INFECTION
Piazuelo Ortega, Elena • Identification of environmental and genetic risk factors for injuries and complications

Roncales Lazaro, Pilar of gastro-intestinal mucosa, development of prevention and treatment strategies.
Sainz Samitier, Ricardo • Biological and molecular mechanisms of neoplastic progression in Barrett’s esopha-

Sopea Biarge, Federico gus:identificationofnewbiomarkersand therapeutictargetsforchemoprevention.
Strunk Groot, Mark
• Identification of effective bactericide compounds against Helicobacter pylori infec-

tion.
GENETIC AND ENVIRONMENTAL DETERMINANTS INVOLVED ON INFLAMMATORY OR

TUMOUR PROCESSES OF THE DIGESTIVE TRACT
• Genetic susceptibility and Helicobacter pylori infection associated with the develop-

ment and prognosis of gastric cancer.
• Study of the genetic basis of susceptibility to hereditary and familial colon cancer.

• Diagnostic and Therapeutic Targets.
STEM CELLS AND CELL THERAPY FOR DIFFERENT DIGESTIVE AND LIVER GASTROIN-
TESTINAL DISEASES.

• Identification, separation and molecular characterization of cancer stem cells in
esophageal cancer .
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•Optimizationof isolationandcultureof humanhepatocytestobeusedforcell
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therapy source. Investigation of the role of bone marrow stem cells in liver regen-
T
R
eration in different human models of disease. PO
• Bioengineering of organs and tissues (hepatic and pancreatic). Cellular therapies are
E
L R
being developed in patients, in a clinic level just like expansion of human stem cells
A
of fetal and adult liver. NU
N
IDENTIFICATION OF BIOACTIVE COMPOUNDS AGAINST PROTEIN TARGETS RELATED A
WITH DIGESTIVE PATHOLOGIES. Transport and selective release by using multifunc- /
HD
tionalnanoparticles andnanosphere/nanoaggregatedpolymers E
• Selected targets are associated with colon cancer (BFT), pancreatic cancer (NUPR1),
ER
IB
Clostridiumdifficileinfection(DPC)and viralhepatitisC(HCVNS3protease).We C
workwithgoldnanoparticles(NP)asnanospheres/nanoclustersof polymersfor
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drug transport and release.