Page 104 - MemoriaEHD-Eng

RESEARCH GROUPS

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PROGRAMME:
G0017
Cholestasis and Metabolic
Disorders

Group Members
Lead Researcher

Mato De la Paz, José Ma
STAFF MEMBERS
Fernndez lvarez, Sara

Fernndez Ramos, David
Contact:
óGonzlez Lahera, Aintzane
CIC BIOGUNE.
Royo Lpez, Flix Mig
Parque Tecnolgico de Bizkaia Edificio 800. Varela Rey, Marta
Phone: (+34) 94 657 25 17

E.mail: [email protected] · Website: www.cicbiogune.es
ASSOCIATED MEMBERS
Abrescia, Nicola Gerardo

Aransay Baares, Ana Mara
Beraza Aguilar, Naiara Main lines of research

Elortza Basterrika, Flix
Falcn Prez, Juan Manuel At present, the aim of our work is to study metabolic alterations as a tool

Martnez Chantar, Ma Luz
and target for the detection, prevention and treatment of nonalcoholic ste-
atohepatitis (NASH) including its progression to liver cirrhosis and cancer.

To this end, we utilize state-of-the-art metabolomic, proteomics, genomic,

structural biology and molecular imaging technologies together with biologi-
cal systems of increasing complexity, including cellular systems, genetic en-

gineered mouse models and human prospective studies. The specific areas

of research are:

• We investigate the regulation of S-adenosylmethionine (SAMe) biosynthesis
in mammalian cells and the function of SAMe in fatty liver disease, liver cir-

rhosis, and cancer.
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• New molecular mechanisms in the development and progression of nonal- T
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coholic fatty liver disease (NAFLD) to liver cancer: unraveling the impact of PO
the post-translational modifications.
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L R
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• Application of “omics” technologies to the study of the composition and NU
function of hepatic exosomes: application to the identification of new non- N
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invasive biomarkers of liver diseases.
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• Structural virology of envelope and lipid-containing viruses: host-recogni- E
ER
tion and assembly.
IB
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• We offer state-of-the-art technological services in genomics, proteomics
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and metabolomics to all members of CIBERehd.