Page 106 - MemoriaEHD-Eng

RESEARCH GROUPS

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PROGRAMME:
G0067
Cholestasis and Metabolic ó
Disorders

Group Members
Lead Researcher

Medina Cabrera, Juan F.
STAFF MEMBERS
Arcelus Echavarri, Sara

Portu Garca, Ainhoa
Contact:
ASSOCIATED MEMBERS
Fundacin para la Investigación Médica Aplicada.
Avda. Pio XII, 55. Celay Leoz, Ion
Concepcin Gonzlez, Axel Rolando
E.mail: [email protected]
Website: https://www.cima.es/areas/terapia-genica-y-hepatologia
Garca Gonzlez, Nicols
Lpez Martnez, Mara

Rodrguez Ortigosa, Carlos
Sez De Blas, Elena
Main lines of research
Sarvide Plano, Sarai

• Molecular genetics of intrahepatic cholestasis; the role of the AE2 anion
exchanger in the etiopathogenesis of primary biliary cirrhosis; ursodeoxy-

cholic acid and AE2.

• Analysis of hepatic and immunologic phenotypes of the Ae2-deficient mice

(in collaboration with Dr. Oude Elerink, AMC, Amsterdam).
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• Role of NO species for the choleretic effect of ursodeoxycholic acid and T
other bile salts.
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• Involvement of bile acids in liver regeneration.
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• Effects of IGF-I on an animal model of primary sclerosing cholangitis.
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• Analysis of the purinome in the biliary tree (in collaboration with Dr. M. A
Pastor-Anglada, CIBERehd).
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