Page 138 - MemoriaEHD-Eng

RESEARCH GROUPS

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PROGRAMME:
G00V4
Liver Cancer and Cancer of
the Digestive System

Group Members
Lead Researcher

Padillo Ruiz, F. Javier
ASSOCIATED MEMBERS

Alamo Martnez, Jos Ma
De La Portilla De Juan, Fernando

Contact:
Gmez Bravo, Miguel ngel
Limn Mirn, Ma Luisa
E.mail: [email protected]
Mrquez Galn, Jos Luis
Website: http://www.ibis-sevilla.es/investigacion/oncohematologia-y- Muntane Relat, Jordi
genetica/cirugia-oncologica-terapia-celular-y-trasplante-de-organos/
francisco-javier-padillo-ruiz.aspx
Pascasio Acevedo, Juan Manuel

Main lines of research

• REGULATION OF CELL DEATH AND PROLIFERATION AND THEIR RELATION
WITH THE THERAPEUTIC EFFICACY IN HEPATOCARCINOMA. ROLE OF P53

GENE FAMILY MEMBERS AND OXIDATIVE/NITROSATIVE STRESS
We investigate the alteration of cell death and proliferation signaling du-

ring treatment with Sorafenib and immunosuppressive agents (Everolimus
13
vs Sirolimus). The project includes a descriptive follow-up study of pa- 20
tients with hepatocellular carcinoma, as well as various experimental in T
R
vitro and in vivo using established hepatoma cell lines. In particular, the PO
role of p53 gene family members, the degree of tumor differentiation and E
L R
oxidative/nitrosative stress will be associated with the antitumor activity of A
NU
the treatments.
N
• GENETIC AND FUNCTIONAL CHARACTERIZATION OF PANCREATIC CAN- A
/
CER. CLINICAL AND EXPERIMENTAL MODELS. HD
E
The project investigates the involvement of PTEN/PI3K/AKT/mTOR signa- ER
ling pathways in pancreatic cancer. Different experimental cellular models, IB
C
as well as tumor implantation in nude mice will be developed in order to
138
evaluate the role of several Ras-related therapeutic strategies in the induc-