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tion and progression of pancreatic cancer. The effect of various inhibitors of the

signaling pathway is studied in pancreatic tumor cells.
•
LIVER REGENERATION BY INFUSION OF STEM CELLS IN THE LIVER. CLINICAL
AND EXPERIMENTAL MODELS.

The project investigates the functional impact of the infusion of bone marrow
stem cells in patients undergoing extended liver resection. Different clinical pa-

rameters of tissue regeneration, as well as the presence of stem cells in liver

and peripheral blood with characteristics of hepatocellular differentiation will be
assessed.

Most relevant • goNzáLez r, FerríN g, aguiLar-MeLero p, raNChaL i, LiNares Ci, BeLLo ri. Targeting hepatoma
using nitric oxide donor strategies.Antioxid Redox Signal. 2013 Feb 10;18(5):491-506.
scientific
• C D, L e, B i, a aM, M-a e, B J. Cardiotro-
articles
astañoareQuieLzastuDiLLoartíNezNsóaLsiNDe
phin-1 eliminates hepatic steatosis in obese mice by mechanisms involving AMPK
activation.J Hepatol. 2013 Dec 19;.

• M Ma, g-r a, s B, r s, M Má, g L, r p,
oBasheroNzáLezoDríguezaNtaMaríaaMosartíNoyaaDa
Letzig L, JaMes Lp, CuaDraDo a, MartíN-pérez J, siMpsoN KJ, MuNtaNé J, vaLverDe aM. Pro-
tein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways

in acetaminophen-induced hepatotoxicityCell Death & Disease . 2013;4:e626.

• vaQuero J, Briz o, herraez e, MuNtaNé J, MariN JJ. Activation of the nuclear receptor

FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against
genotoxic compounds.Biochim Biophys Acta. 2013 Oct;1833(10):2212-9.

• vaQuero J, MoNte MJ, DoMiNguez M, MuNtaNé J, MariN JJ. Differential activation of the

human farnesoid X receptor depends on the pattern of expressed isoforms and the í
bile acid pool composition.Biochem Pharmacol. 2013 Oct 1;86(7):926-39.

During 2013 we have developed a research project to identify the alteration of
Highlights
cell death and proliferation signaling by Sorafenib and immunosuppressants (eve- í
rolimus vs sirolimus) (CTS- 6264, Consejería de Economía, Innovación, Ciencia

y Empleo) and three research projects related to cell therapy in the context of

liver regeneration in large resections (CMMO/RH/2009, Instituto de Salud Carlos
III; PI-0540/2010, Consejera de Salud), promoting immunosupression in liver

transplantation (PI-0385/2010, Consejera de Salud) and the treatment of anal
fistulas in Crohn’s disease without concomitant therapy with second-line drugs

(EC11-450, Instituto de Salud Carlos III). Twenty five articles have been published

including original and reviews, comprising all scientific areas in which the group is
involved. Also, there were presented two patents “ Kit for the decommissioning of

large cutaneous wounds after abdominal surgery “ (P- 06165 ) and “Effectiveness 13
20
of nitric oxide to treat differentiated, but not poorly differentiated, liver cancer T
cells” (FISEVI-13007).
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