Page 178 - MemoriaER-Eng
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RESEARCH GROUPS
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PROGRAMME:
Group U757
Hereditary Cancer and
Related Syndromes
Group Members
Lead Researcher
Perona Abellón, Rosario
STAFF MEMBERS
Manguan Garca, Cristina
Contact:
ASSOCIATED MEMBERS
Carrillo Garca, Jaime
Instituto de Investigaciones Biomédicas CSIC/UAM
C/ Arturo Duperier, 4. 28029 Madrid Machado Pinilla, Rosario
Snchez Prez, Isabel
Phone: (+34) 91 585 44 63
E.mail:[email protected]
Sastre Garzn, Leandro
Main lines of research
• Application of a rescue therapy in diseases associated with telomerase
activity deficiency. Signalling pathways active in dyskeratosis congenita in
response to DNA damage. Improve the activity of nanoparticles and lenti-
viral vectors for gene therapy.
• Development of a therapy base in the GSE24.2 peptide fro the treatment of
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short telomeres associated diseases, increase oxidative stress and geentic 20
instability.
T
R
• Genetic diagnosis of DC y study of telomere lenght in patients of DC and PO
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idiophatic pulmonary fibrosis. Study of models of idiopathic pulmonary L R
fibrosis using stem cells and KO mouse models for DUSP1.
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NU
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• Investigation about the activity of GSE24.2 for the treatment of idiophatic A
pulmonary fibrosis.
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• Use of GSE24.2 for the treatment of ataxia telangiectasia.
ER
B
CI
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