Page 178 - MemoriaER-Eng
P. 178




RESEARCH GROUPS








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PROGRAMME:
Group U757
Hereditary Cancer and 
Related Syndromes




Group Members
Lead Researcher

Perona Abellón, Rosario
STAFF MEMBERS
Manguan Garca, Cristina


Contact:
ASSOCIATED MEMBERS
Carrillo Garca, Jaime 
Instituto de Investigaciones Biomédicas CSIC/UAM 
C/ Arturo Duperier, 4. 28029 Madrid Machado Pinilla, Rosario 
Snchez Prez, Isabel 
Phone: (+34) 91 585 44 63 
E.mail:[email protected]
Sastre Garzn, Leandro



Main lines of research


• Application of a rescue therapy in diseases associated with telomerase 

activity deficiency. Signalling pathways active in dyskeratosis congenita in 
response to DNA damage. Improve the activity of nanoparticles and lenti- 

viral vectors for gene therapy.

• Development of a therapy base in the GSE24.2 peptide fro the treatment of 
13
short telomeres associated diseases, increase oxidative stress and geentic 20
instability.
T 
R
• Genetic diagnosis of DC y study of telomere lenght in patients of DC and PO
E
idiophatic pulmonary fibrosis. Study of models of idiopathic pulmonary L R
fibrosis using stem cells and KO mouse models for DUSP1.
A
NU
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• Investigation about the activity of GSE24.2 for the treatment of idiophatic  A
pulmonary fibrosis.
 /
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• Use of GSE24.2 for the treatment of ataxia telangiectasia.
ER
B
CI


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