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prescribing/dispensing/use of antibiotics in order to reduce their resistances. We are

also developing studies to further identify the genetic factors of adverse reactions to

drugs most relevant from the point of view of public health, such as gastrointestinal
bleeding.

• TECHNOLOGY ASSESSMENT AND HEALTH SERVICES. Our group aims to provide sup-

port within a consolidated evaluation activity such as technology assessment, services

and health interventions through various mechanisms, one of them being the syste-
matic reviews and the meta-analysis. The meta-analysis is the knowledge evaluation

system more widely used in epidemiology. The level of evidence derived from the

meta-analysis is the highest and exceeds the experimental design. The objective in
the following years is to propose a free-use package software that allows the non spe-

cialized scientific community to perform intuitively and with a minimal advice a meta-
analysis from the first steps to the final proposal. This project is in a very advanced

state of development. Also, the methodological elements will be investigated, such as

heterogeneity and publication bias, and these methodological knowledge will be used íá
to apply to specific meta-analysis, collaborating with the clinical services interested.

áá
Most relevant • tAKKoucHe b, KHuDyAKoV p, costA-bouzAs J, spiegelMAn D. Confidence intervals for hetero-
geneity measures in meta-analysis.Am J Epidemiol. 2013 Sep 15;178(6):993-1004.
scientific
• t r A, r F, F A, F A, H Mt. Understanding physi-
articles
eixeirAoDriguesoqueAlcãoigueirAserDeiro
cian antibiotic prescribing behaviour: a systematic review of qualitative studies.Int J ó
Antimicrob Agents. 2013 Mar;41(3):203-12.
ó
• M-s V, F A. Central nervous system demyelinating diseases
ArtnezernnDezigueirAs
and recombinant hepatitis B vaccination: a critical systematic review of scientific

production.J Neurol. 2013 Aug;260(8):1951-9.
á

• gonzlez-gonzlez c, lpez-gonzlez e, HerDeiro Mt, FigueirAs A. Strategies to improve
adverse drug reaction reporting: a critical and systematic review.Drug Saf. 2013 á

May;36(5):317-28.

• ruAno-rAVinA A, AlDAMA-lpez g, ciD-lVArez b, piñón-estebAn p, lópez-otero D, cAlViño-
s r. Radial vs Femoral Access After Percutaneous Coronary Intervention for ST-
Antos
segment Elevation Myocardial Infarction. Thirty-day and One-year Mortality Results.
Rev Esp Cardiol. 2013 Nov;66(11):871-878.

During 2013 the research line in cancer epidemiology has had 3 projects financed,
Highlights
two from the FIS and one regional. Between 2013 and 2014 several articles have
been published in the first decile and quartile journals, essentially studies related

to the multicenter research on lung cancer in never smokers and ecological stu-
dies linking exposure to residential radon with various tumours. The DNA-repair 13
20
project has been initiated which aims to include 1,400 subjects in the next 3 years T
OR
and to analyze the biological mechanism through what radon causes lung cancer.
P
RE
The members of the research line in pharmacoepidemiology have participated in L
two research projects, one from the FIS and the other one financed by the FTC (Fi- A
NU
nancing Agency in Portugal). During 2013 and 2014 members from this research N
A
line have collaborated as editors at a journal in the first quartile (Drug Saf), and P /
have published articles in first decile (JAMA) and quartile (Drug Saf, J Neurol, Int S
RE
J Antimicrob Agents) journals.
E
IB
C

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