Page 112 - MemoriaESP-Eng

RESEARCH GROUPS

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PROGRAMME:
Ep. and Prev. Environmental Grupo de Mutagenesis

and Occupational Diseases

Group Members
Lead Researcher

STAFF MEMBERS
Marcos Dauder, Ricardo

Pastor Benito, Susana
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Contact:
èASSOCIATED MEMBERS
Alarcn Snchez, Lourdes
Departament de Gentica i de Microbiologia
Universidad Autonoma de Barcelona Creus Capdevilla, Amadeu

Edifici C (Fac. Biocincies) Campus UAB. 2a Pl. 08193 Cerdanyola del Vallès Guillamet Cros, Emma
Phone: (+34) 93 581 20 52 · E.mail: [email protected] Hernndez Bonilla, Alba

Website: http://grupsderecerca.uab.cat/mutagenesi/
Soriano Tarraga, Carolina
Velzquez Henar, Antonia

Xamena Lpez, Noel
Main lines of research

• GENOTOXIC/CARCINOGENIC MECHANISMS OF ARSENIC
This research field involves both in vitro and biomonitoring studies with exposed popula-

tions. The most interesting recent results can be summarized as:
- In the human populations studied (Chile and Mexico), the exposed people (never mind

if they are occupationally or environmentally exposed) present high levels of genetic
damage.

- We have found a new polymorphism of the AS3MT gene (Met287Thr) acting as an im-
portant modulator of the genetic risk. Individuals carrying such variant accumulate the
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metabolite MMA(III) that is the arsenic specie showing the highest genotoxic potentiality. 20
- We have generated a wide set of in vitro tools to evaluate the carcinogenic potential of
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arsenic. PO
- We have demonstrated for first time that oxidative damage plays an important role in
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L R
both the genotoxicity and carcinogenicity of arsenic. A
• RISK FACTORS IN PATIENTS WITH THYROID PATHOLOGIES
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The most important goals reached in this research line can be summarized as follows: A
- We have found a region in chromosome 1p12 showing a strong association with thyroid /
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cancer. In this region there is a new gene (WDR3) responsible of the observed association. RE
- We have found associations between different genes involved in the repair of DNA (OGG1,
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XRCC1, XRCC2 and XRCC3) and the metabolism of thyroid (TG) and the thyroid cancer. C
- In a wide study of all the genome (GWA), carried out with samples from four European
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populations we have found a strong association with the rs6759952 polymorphism of the
DIRC3 gene.