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- Finally, in a collaborative study with Italian groups we have shown for first time that the

thyroperoxidase gene (TPO) is involved in the risk of suffering thyroid cancer.
• RISK FACTORS IN PATIENTS WITH KIDNEY THYROID PATHOLOGIES

The most important recent goals of this research line are as follows:
- We have found that patients with chronic renal failure (CRF) present high levels of ge-

netic damage at both primary and fixed level.
- The CRF patients are characterized by genomic instability. This supposes that these pa-

tients are extremely sensitive to the environmental genotoxicants.
- CRF patients present high mortality, but not specific causes have been found.

- DNA oxidative damage and its inability to repair it is an important factor explaining why
these patients show high levels of genetic damage.

• GENOTOXIC MECHANISMS OF NANOMATERIALS.

This is a recent research line aiming to determine the risk that can suppose the presence of
these new materials in our near environment.
ö
The obtained results until now indicate that
- Silver in its nanoparticulated form is able of induce genotoxic damage in vivo as we have
demonstrate in Drosophila.

- We have detected several nanomaterials such as titanium dioxide and zinc oxide modulate
the genotoxic effects induced by UV light.

- Long-term exposures to sub-toxic doses of cobalt nanoparticles induce cell transformation
as well as other markers of tumoral processes. í
ó
- Cerium nanoparticles pose antioxidant potential both in vivo and in vitro.

• c M, p s, g F, c J, g s, b A. TPO genetic variants
Most relevant ipolliniAstoreMignAniAstellArritAnoonotti
and risk of differentiated thyroid carcinoma in two European populations. Int J Can-
scientific cer. 2013 Dec 15;133(12):2843-51.
é

articles
• p A, M r, s-r A, s-c o, l-g gH, H
AstoretArcosAMpAyoeyesAuceDoArDenAsozAnoArzAernánDez
A. Inhibition of hepatocyte nuclear factor 1 and 4 alpha (HNF1α and HNF4α) as a
mechanism of arsenic carcinogenesis. Arch Toxicol. 2013 Jun;87(6):1001-12.

• K A, c b, g F, e r, r c, F g. Genome-wide association study
HlerHeneMignAniliseioMeiiglioli
on differentiated thyroid cancer.J Clin Endocrinol Metab. 2013 Oct;98(10):E1674-81.

• VAles g, DeMir e, KAyA b, creus A, MArcos r. Genotoxicity of cobalt nanoparticles and ó
ions in Drosophila. Nanotoxicology. 2013 Jun;7(4):462-8.

• l i, b c, i-p l, s-p A, p s, V A. An epistatic
AnDAoullosAnglADArezAstreeronAAstorelázquez
interaction between the PAX8 and STK17B genes in papillary thyroid cancer suscep-
tibility. PLoS One. 2013;8(9):e74765.

A total 10 publications with an accumulated impact factor of 41.268 have been publis-
Highlights
ó
hed. This means an averaged factor of 4.13.
Two research projects have been obtained. One supported by FIS in collaboration
13
with the Fundacin Puigvert entitled: Biomarcadores de pronstico y estrategias para ó20
disminuir la morbimortalidad de pacientes con insuficiencia renal. The second one has T
OR
been funded by the UE and entitled: A common European approach to the regulatory P
testing of nanomaterials (NaNoREG).
RE
L
Defence of one PhD Thesis entitled: El proyecto NanoGenotox: Hacia el desarrollo de A
NU
una metodologa robusta para la determinacin del potencial genotxico de los nano- N
materiales.
A
P /
Presentation of two communications at the 52th SOT (Society of Toxicology) Annual S
Meeting held at San Antonio, USA.
RE
E
Ricard Marcos and Susana Pastor acted as experts, nominated by the Ministerio de Sa- IB
C
nidad y Consumo, in the ad hoc Commission of the OCDE responsible for the revision
and updating of the Guidelines on Genotoxicity Assays.
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