Page 143 - MemoriaESP-Eng

www.ciberesp.es

• r, M; b, x; A, i; F, M; A, D;
Most relevant iVerAArcelAAsAgAnAAVierguilerAnMAculADAorAsterAriAgisAViDDe
groot, eric; pérez, lAurA; MenDez, MicHelle A.; bouso, lAurA; tArgA, JAuMe; rAMos, rAFAel;
scientific s, J; M, J; e, r; K, n. Association between Long-
AlAoAnArrugAtAuMelosuAobertounzliino
articles
Term Exposure to Traffic-Related Air Pollution and Subclinical Atherosclerosis: The

REGICOR StudyENVIRONMENTAL HEALTH PERSPECTIVES. 2013;.

• JulVez J, AlVArez-peDrerol M, rebAgliAto M, MurciA M, Forns J, gArcíA-estebAn r et Al..
Thyroxine levels during pregnancy in healthy women and early child neurodevelop-

ment.Epidemiology. 2013 Jan;24(1):150-7.

• AguilerA i, peDersen M, gArcíA-estebAn r, bAllester F, bAsterrecHeA M, esplugues A et
.. Early-life exposure to outdoor air pollution and respiratory health, ear infec-
Al
tions, and eczema in infants from the INMA study.Environ Health Perspect. 2013
Mar;121(3):387-92.

• c M, c l, c Ae, A p, g M, K M .. Maternal pre-
AsAsHAtziArsinMiAnouxensogeVinAset Al
pregnancy overweight and obesity, and child neuropsychological development: two
í
Southern European birth cohort studies.Int J Epidemiol. 2013 Apr;42(2):506-17.

• DonAire-gonzález, DAViD; giMeno-sAntos, elenA; bAlcells, eVA; roDríguez, Diego A.; FA-
rrero, eVA; De bAtlle, JorDi; benet, MArtA; Ferrer, Antoni; bArberA, JoAn A.; geA, JoAquiM;

roDrguez-roisin, robert; Anto, Josep M.; gArcíA-AyMericH, JuDitH. Physical activity in
COPD patients: patterns and boutsEUROPEAN RESPIRATORY JOURNAL. 2013;.

Pre and post-natal life are critical periods in the origins of chronic diseases, such
Highlights
as obesity, the metabolic syndrome, cognitive development, and the origins of

asthma and allergy. However, our current understanding of how chronic diseases
develop during fetal life and childhood is still very limited. Still few isolated risk

factors have been assessed and its causal mechanisms are poorly understood. We
propose that:

1. The epidemiological studies by applying birth cohorts from the general popula-

tion is a successful strategy for unraveling the complex multicausal origins of

chronic disease.

2. Potentially harmful environmental and behavioral factors should be assessed at
a much wider scale thought a better integration of the omics. This has been sig-

nificantly consolidated with the leadership (PI M Vrijheid) of the Helix Project to

develope the exposome in birth cohorts and the leadership of J Garcia-Aymerich
developing new methods for unsupervised statistics.

3. The integration of imaging together with the ‘exposome’ in epidemiological

studies opens new opportunities for understanding the underlying mechanisms.

An area of particular interest in our group is the understanding of which and how
environmental risks play a detrimental role on neurodevelopment during the

fetal and first years of life, an effort promoted by the ERC-Adv Breathe project 13
20
(PI J Sunyer).
T
OR
4. The alliance with CRESIB under the ISGlobal opens opportunities to enlarge P
studies to a global context.
RE
L
5. The environmental determinants of respiratory diseases are leading causes of A
NU
DALYs worldwide: particulate matter, physical inactivity and low physical activity N
A
occupational particulate matter, gasses and fumes, ozone pollution and occupa- P /
tional asthmogens. Increasing research shows that asthma and COPD are com- S
RE
plex phenotypes whose definitions and classification need to be reconsidered. We E
IB
have consolidated as scientific leaders in these fields, by leading and participat- C
ing in large national and international projects.
143