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• W rA, A A, c d, d r, d t, d B. Tiotropium Respimat inhaler
Most relevant iSenZuetoottonAHleVinSiSSe
and the risk of death in COPD.N Engl J Med. 2013 Oct 17;369(16):1491-501.
scientific
• SuAreZ-SiPMAnn F, BorgeS JB. How we stretch the lung matters.Crit Care Med. 2013
articles
Apr;41(4):1153-5.

• PéreZ-riAl S, del Puerto-neVAdo l, terrón-eXPóSito r, girón-MArtíneZ á, gonZáleZ-MAngAdo
n, PeceS-BArBA g. Role of recently migrated monocytes in cigarette smoke-induced

lung inflammation in different strain of mice.PLoS One. 2013;8(9):e72975.

• FerrArini A, ruPéreZ FJ, erAZo M, MArtíneZ MP, VillAr-álVAreZ F, PeceS-BArBA g et Al..
Fingerprinting-based metabolomic approach with LC-MS to sleep apnea and

hypopnea syndrome: a pilot study.Electrophoresis. 2013 Oct;34(19):2873-81.

• de-torreS JP, BlAnco d, AlcAide AB, SeiJo lM, BAStArrikA g, PAJAreS MJ. Smokers with CT
detected emphysema and no airway obstruction have decreased plasma levels of

EGF, IL-15, IL-8 and IL-1ra.PLoS One. 2013;8(4):e60260.

Our group coordinates the WP4 of the CRP of COPD on animal models of COPD, as
Highlights
translational support of WP 1 and 3 and has secured funding for it in the AES2013

call with a coordinated research project, under a PI belonging to our group with
the participating of 5 CIBERES groups (PI13/01909). Within this WP4, we are

studying in animal models the factors that determine the start of the development

of COPD in response to the tobacco smoke and we described the contribution of
monocytes in the beginning of disease.

Our participation in the CRP of OSA has featured as main result the ability to diag-

nose and stage the disease by metabolomic analysis of plasma patients.

Regarding participation in the CRP of cancer, initiated in 2013, we note that it has
been approved the project for “Early detection of lung cancer” by using low dose

CT in the high-risk population of patients with COPD.

Finally, we consider as relevant our participation the clinical guide of “Spirometry”

pf SEPAR and the continued contribution to the recruitment of clinical cases of the
coordinated projects of the three CRP.

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