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• Q M, g-M M c, V-A V, g c, o A, F r ..
Most relevant uinteroonZAleZArtíndelegAgAPitoonZAleZBeSoArréet Al
The effects of intermittent hypoxia on redox status, NF-κB activation, and plasma
scientific lipid levels are dependent on the lowest oxygen saturation.Free Radic Biol Med. 2013

articles
Dec;65:1143-54.

• riBeiro MJ, SAcrAMento JF, gonZAleZ c, guArino MP, Monteiro ec, conde SV. Carotid body

denervation prevents the development of insulin resistance and hypertension indu-
ced by hypercaloric diets.Diabetes. 2013 Aug;62(8):2905-16.

FINANCIAL SUPPORT OBTAINED IN 2013
Highlights
• BFU2012-37459. Ministerio de Economía y Competitividad. DGICYT (2012-2014)

Project title: Physiopathologicl mechanisms of the cardiovascular arterations
encountered in the obstructive sleep apnea: foundations for therapeuctic

designs. Budget: 222.300€. PI. Constancio Gonzalez.

• Asociación Española Contra el Cancer (A predoctoral Fellowship in Oncology) í

(2013-2015) Project title: Obstructive Sleep Apnoea Syndrome and Cancer.
Budget: 56.000€. PI: Constancio Gonzalez. Fellowship recipient: Teresa Gallego

Martn.

MOST RELEVANT FINDINGS IN 2013

We have found that a hypercaloric diet induces resistance to insulin and arterial

hypertension, which are accompanied by a sensitization status of the carotid body
arterial chemoreceptors. We also found that the carotid body sensitization is pro-

duced by the augmented insulin level. In turn, carotid body sensitization causes

a sympathetic hyperactivity which is responsible for arterial hypertension and in-
sulin resistance. A positive feed-back is generated that maintains and aggravates

the cardiovascular and metabolic alterations present in obesity. The denervation
of the carotid body eliminates hypercaloric diet induced insulin resistance and

hypertension.

In another front, we have found that intermittent hypoxia mimicking obstructive

sleep apnoea causes an oxidative damage characterized by a downregulation of
the mitochondrial superoxide dismutase and activation of NFkB transcription fac-

tor. NFkB, in turn, upregulates the expression of inflammatory cytokines, which

also generate oxidative damage. These alterations are proportional to the level of
haemoglobin desaturation. Our findings provide an explanation to the oxidative

and inflammatory status encountered in patients with obstructive sleep apnoea.

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