Page 134 - MemoriaES-Eng

RESEARCH GROUPS

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PROGRAMME:
Group 28

Acute Lung Injury

Lead Researcher
Group Members

STAFF MEMBERS
Prez Vizcaíno, Francisco
Barreira Barba, Bianca

íMartnez Ramas, Andrea
Contact:
Moreno Gutirrez, Laura
Dpto. de Farmacologa. Facultad de Medicina
Ciudad Universitaria Avda. Complutense S/N. Madrid ASSOCIATED MEMBERS
Cogolludo Torralba, ngel Luis
Phone: (+34) 91 394 14 77 · E.mail: [email protected]
http://www.ucm.es/farmacologia/farmacologia-vascular-factores-vasoactivos
Morales Cano, Daniel
Pandolfi, Rachele

Main lines of research

Pulmonary hypertension is a condition characterized by increased pulmonary

vascular resistance with a complex and not well characterized pathophysiol-
ogy. Our interest is mainly focused on the mechanisms involved in pulmonary

vasodilation and inhibition of cell proliferation in order to identify and design

new drugs that are potentially useful in the treatment of pulmonary hyper-
tension.

Acute lung injury (ALI ) or its more severe form, acute respiratory distress
syndrome (ARDS ) is characterized by pulmonary edema and alveolar col- 13
20
lapse leading to severe arterial hypoxemia. Although the protective ventila- T
R
tory support strategies have improved the prognosis of patients, the associ- PO
ated mortality remains unacceptably high. Our interest is to characterizie the E
L R
pulmonary vascular inflammatory response associated with acute lung injury A
and the identification of therapeutic targets to improve prognosis in these NU
N
patients.
A
/
Our research work is focused in analyzing different signaling pathways in- ES
volved in these pathologies: 1) Sphingolipids, components of the plasma ER
B
membrane of all eukaryotic cells whose hydrolysis products (ceramides and CI
sphingosine) play a key role in various signal transduction pathways. 2) In-

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nate immunity receptors and danger-associated molecular patterns.