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The principal aims of this programme are:
Aims and 

objectives
1. To study the risk, and prognosis factors of severe acute community-ac- 

quired and ICU-acquired respiratory infections in Spain, including bio- 
markers and genetic factors.

2. To study risk, and prognosis of community-acquired and hospital acquired 

respiratory infections in patients not admitted to the ICU in Spain, also 

including biomarkers.

3. To study in depth the microbial etiology and resistances of all the populations 
mentioned above. In this objective we will include the investigation of new rapid 

molecular techniques.

4. To study whether the implementation of educational programmes and bun- 

dles may decrease the incidence of hospital-acquired pneumonia inside and out- á
side the ICU.
í


5. To investigate the best way to treat multiresistant microorganisms.

6. To investigate the epidemiology, virulence, inflammatory response and 
clinical outcomes of serotypes of S. pneumoniae causing invasive disease 
í
before and after the introduction of the new vaccine PVC 13.

7. To investigate new mechanisms of virulence, resistance and treatment of 
í
S. pneumoniae.

8. To use our available animal models of severe pneumonia (P. aeruginosa, 
MR S. aureus and S. pneumoniae) for translational research.
í


9. To develop new clinical guidelines for the management of community-acquired 
pneumonia, hospital-acquired pneumonia and ventilator-associated pneumonia.




é

óó
Guidelines:
Main results 

in 2013
• Gua multidisciplinar para la valoracin pronóstica, diagnóstico y tratamien- ú

to de la neumona adquirida en la comunidad. Antoni torreS*, JoSé BArBe- 

rn, MiQuel FAlguerA, roSArio MenndeZ, JeSS MolinA, Pedro olAecHeA Y Ale- 
r, en nombre del Grupo de la Guía Multidisciplinar para el 
JAndro odrgueZ
Manejo de la Neumona Adquirida en la Comunidad; 1,2 Med Clin (Barc). 
2013;140(5):223.e1–223.e19.


• A care bundle approach for prevencin of ventilator-associated pneumonia. 13
r J, A e, l t, r M, B B, r A, V J, d e; Investi- 20
elloFonSoiSBoAicArtAlSerAoVirAAlleSíAZT 
gadores del proyecto FADO. Clin Microbiol Infect. Abril de 2013; 19(4):363-9.
OR
P
RE
L 
Publications:
A
NU
N
 A
• Intensive Care Med. Abril de 2013; 39(4):672-81. Potentially resistant mi- S /
croorganisms in intubated patients with hospital-acquired pneumonia: the in- E
ER
teraction of ecology, shock and risk factors. MArtin-loecHeS i1, deJA M, koulenti B
CI
d, diMoPouloS g, MArSH B, torreS A, niederMAn MS, rello J; Investigadores del 
estudio EU-VAP.

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