Page 91 - MemoriaES-Eng

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• V J, P M, A-l F, r J, B A, g-M J. Evolution
Most relevant AlléSAloMArlVáreZerMAellolAncoArnAcHoontero
over a 15-year period of clinical characteristics and outcomes of critically ill patients
scientific
with community-acquired bacteremia. Crit Care Med. 2013 Jan;41(1):76-83.
articles
• Puig F, FuSter g, AddA M, BlAncH l, FArre r, nAVAJAS d et Al.. Barrier-protective effects of
activated protein C in human alveolar epithelial cells. PLoS One. 2013;8(2):e56965.

• g-l A, l-A i, A A, A-r l, B-S e, A-
onZáleZóPeZóPeZlonSoguirreMAdoodrígueZAtAllAolíSStudi
llo A. Mechanical ventilation triggers hippocampal apoptosis by vagal and dopami-
nergic pathways. Am J Respir Crit Care Med. 2013 Sep 15;188(6):693-702.

• F r, g g, V A, l-A J, A A. Assessment of the inflam-
ernándeZiliillAgrAoPeZguilArrtigAS
matory effect of low-dose oxygen in mechanically ventilated patients. Intensive Care
Med. 2013 Apr;39(4):711-6.

• M-l i, d M, k d, d g, M B, t A. Potentially
ArtínoecHeSeJAoulentiiMoPouloSArSHorreS
resistant microorganisms in intubated patients with hospital-acquired pneumo-

nia: the interaction of ecology, shock and risk factors.Intensive Care Med. 2013
Apr;39(4):672-81.

• We have developed and validated a monitoring system (spin-off Better-Care and
Highlights
patent US2010106825). We have registered more than 160 patients in 5 ICU’s,
during the whole ventilatory period. This study has revealed the high incidence of

asynchronies and its association with the risk of ICU mortality (financed projects
in this field PI13/02204, TSI-020302-2010-134).

• We have demonstrated that the PEEP modulates the inflammatory response
andtheneuronalactivationandapoptosisinanALIexperimentalmodel (PMID

23962032).

• We have demonstrated that tissue oxygenation monitoring is useful to determine

the weaning outcome in ventilated patients (PMID 23314894).

• Tracheal ischemia could be prevented by manual or continuous control of cuff
pressure (PMID 24572178).

• Efficacy of single-dose antibiotic prophylaxis at intubation to decrease the inci-

dence of early pneumonia in comatose MV patients (PMID 23715136).

• We have finished the study analyzing the incidence of tracheobronchitis and VAP.

• We have assessed the inflammatory effect of oxygen in mechanically ventilated

patients (PMID 23296630).

• We have applied non-invasive biological monitoring system to detect volatile

organ compounds related to lipid peroxidation in exhaled breath of mechanically
ventilated patients with ARDS.

• Cell Therapy in ARDS based in the transplant of neumocytes type II cells in a 13
sustained ARDS experimental model in rats has demonstrated an improvement 20
T
in lung remodelling (PI12/02548).
OR
P
• We demonstrated the usefulness of anticoagulant treatment with activated pro- RE
L
tein C and heparin in alveolar primary cell cultures, improving and preventing A
cell damage and alveolar permeability (PMID 23451122)
NU
N
• We have signed an agreement to study the effect of Antithrombin in an in vitro A
S /
model of Acute Lung Injury (Grifols).
E
ER
• Educational postgraduate activities: 18th International Symposium on Infections B
CI
in Critically Ill Patients (Sevilla 2013), ATS PG Course “Cardio Respiratory Moni-
toring“ (Philadelphia 2013), Respiratory Applied Physiology (Sabadell 2013),
91
Master in Critical Care.