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Most relevant • PéreZ grAndA MJ, BArrio JM, HortAl J, MuñoZ P, rincón c, BouZA e. Routine aspiration of
subglottic secretions after major heart surgery: impact on the incidence of ventila-
scientific
tor-associated pneumonia. J Hosp Infect. 2013 Dec;85(4):312-5.
articles
• guineA J, PAdillA c, eScriBAno P, MuñoZ P, PAdillA B, giJón P. Evaluation of MycAssayTM
Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without he-

matological cancer. PLoS One. 2013;8(4):e61545.

• iñigo J, gArcíA de ViedMA d, Arce A, PAlenQue e, HerrAnZ M, rodrígueZ e. Differential
findings regarding molecular epidemiology of tuberculosis between two consecutive

periods in the context of steady increase of immigration. Clin Microbiol Infect. 2013
Mar;19(3):292-7.

• BouZA e, grAndA MJ, HortAl J, BArrio JM, cercenAdo e, MuñoZ P. Pre-emptive broad-
spectrum treatment for ventilator-associated pneumonia in high-risk patients. In-

tensive Care Med. 2013 Sep;39(9):1547-55.

• eScriBAno P, PeláeZ t, MuñoZ P, BouZA e, guineA J. Is azole resistance in Aspergillus fumi-
gatus a problem in Spain? Antimicrob Agents Chemother. 2013 Jun;57(6):2815-20.

The CIBER group of the Hospital General Universitario Gregorio Marañón (HGUGM)
Highlights
in Madrid has had a very successful year in 2013, both in scientific research and

in scientific production.
The list of publications of the group, that we include, reached the figure of 70, with

a cumulative impact factor of more tha 240.

The scientific production has been good in the different study areas, the percent-

age of publications in the 1st decile and in the 1st quartile being 12 and 47 re-
spectively.

In the area of ventilator-associated pneumonia, the study of the impact of routine

aspiration of subglottic secretions after major heart surgery on the incidence of

ventilator-associated pneumonia was finished. A second study on the use of pre-
emptive broad-spectrum treatment to prevent ventilator-associated pneumonia in

major heart surgery ICU patients proved to be effective in reducing its incidence
and in delaying the onset of VAP. Still, an increase in the resistance of staphy-

lococci to linezolid was observed in the entire institution. Thus, the ecological

consequences have to be carefully evaluated in future trials, and different drugs
should be tested.

The data on tuberculosis also show further progress in the study areas of the

group. The scientific production has been in the following fields: development of

new low cost techniques directed at Mycobacterium tuberculosis (MTB) genotyp-
ing in molecular epidemiology; development of rapid detection techniques of high-

risk MTB strains; optimizing the detection of clonally complex MTB infections; pop-
ulation-based studies of complex infections (mixed infections and coinfections by 13
20
clonal MTB variants); genotypic and phenotypic analysis of MTB variants emerging T
OR
in microevolution events and assessment of their functional significance.
P
RE
The group of respiratory mycosis has also had a high scientific production particu- L
larly in the fields of invasive aspergillosis, candidiasis and candidemia.
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