Page 99 - MemoriaES-Eng

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• P o, M e, S c, S i, Q k, F A. Antioxidant effect of hu-
Most relevant eñuelASeloáncHeZáncHeZuinnerruelo
man adult adipose-derived stromal stem cells in alveolar epithelial cells undergoing
scientific stretch.Respir Physiol Neurobiol. 2013 Aug 1;188(1):1-8.

articles
• Herrero r, tAnino M, SMitH lS, kAJikAWA o, Wong VA, MongoVin S. The Fas/FasL pathway
impairs the alveolar fluid clearance in mouse lungs.Am J Physiol Lung Cell Mol Phy-

siol. 2013 Sep;305(5):L377-88.

• tHille AW, eSteBAn A, FernándeZ-SegoViAno P, rodrígueZ JM, ArAMBuru JA, PeñuelAS o.
Comparison of the Berlin definition for acute respiratory distress syndrome with

autopsy.Am J Respir Crit Care Med. 2013 Apr 1;187(7):761-7.

• tHille AW, eSteBAn A, FernándeZ-SegoViAno P, rodrígueZ JM, ArAMBuru JA, VArgAS-erráZuriZ
P. Chronology of histological lesions in acute respiratory distress syndrome with

diffuse alveolar damage: a prospective cohort study of clinical autopsies.Lancet Res-
pir Med. 2013 Jul;1(5):395-401.

• e A, F-V F, M A, F nd, P o, A V. Evolution of
SteBAnrutoSiVArurielerguSoneñuelASBrAirA
mortality over time in patients receiving mechanical ventilation.Am J Respir Crit

Care Med. 2013 Jul 15;188(2):220-30.

Our group has continued to develop the main research lines started in recent
Highlights
years.

• The first one, which represents the core of our participation in the CRP on acute
lung injury, is our research in the Acute Respiratory Distress Syndrome (ARDS).

In 2013 we finalized the analysis of the clinico-pathological correlation of the so

called Berlin Definition (Thille A, Esteban A,et al AJRCCM 2013;187:761-767)
as well as on the chronological changes of the histological changes in ARDS

(Thille A,Esteban A, et al The Lancet Respiratory Medicine 2013;1(5):395-401).
We have also written a manuscript on the different clinical phenotypes hidden

under the clinical diagnosis of ARDS (manuscript in preparation). In the area of

biomarkers, we have identified a miRNA that is associated with diffuse alveolar
damage (DAD) in rats undergoing mechanical ventilation-induced lung injury,

and has good diagnostic characteristics in patients on mechanical ventilation

when its expression is measured in the serum (FIS PI12/02898) (manuscript in
preparation) (this project is also the thesis project of one of our fellows). (FIS

PI12/02451).

• The second one is our research on mechanical ventilation. We have published

the largest to date epidemiological study on the use of mechanical ventilation
(Esteban A, Frutos-Vivar F , et al.AJRCCM 2013;188:220-30). We have also

written two more manuscripts on the incidence, risk factors and time course of

patients with ICU-acquired weakness (submitted), and on the effects of seda-
tion of patients receiving noninvasive mechanical ventilation (submitted).
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• The third one is our research on the prevention of respiratory infection in criti- T
OR
cally ill patients. We have finalized a study on the effects of selective digestive P
RE
decontamination in the pulmonary response to mechanical ventilation in rats L
(manuscript in preparation) (this project is also the thesis project of one of our A
NU
fellows). A study on the effect of central line replacement policy in critically ill N
burn patients on catheter related bacteremia is ongoing (FIS PI11/01121).
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