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• Transcription and epigenetic factors in the relationship between obesity and

diabetes. In this line, we analyze epigenetic modifications of certain genes in-
volved in the relation obesity-diabetes and how these modifications are affec-

ting transcription factors that regulate crucial metabolic or signaling pathways
in this relation.

Most relevant • caroBBio s, haGen rM, lelliott cJ, slawiK M, MeDina-GóMez G, tan cy et al.. Adaptive
changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with
scientific
increased storage demands of obesity.Diabetes. 2013 Nov;62(11):3697-708.
articles
• cleMente-PostiGo M, queiPo-ortuño Mi, Boto-orDoñez M, coin-araGüez l, roca-roDríGuez
MM, D-l J .. Effect of acute and chronic red wine consumption on
elGaDoistaet al
lipopolysaccharide concentrations.Am J Clin Nutr. 2013 May;97(5):1053-61.
é
• Bernal-lóPez Mr, GarriDo-sánchez l, GóMez-carrillo V, GalleGo-Perales Jl, llorente-
c V, c F .. Antioxidized LDL antibodies are associated with different
ortésalleJaet al
metabolic pathways in patients with atherosclerotic plaque and type 2 diabetes.
Diabetes Care. 2013 Apr;36(4):1006-11.
é

• t FJ, c a l, M M, o o w, M t MD, B n
inahonesoínráGüezurriliValiVeraayasorresarBarroJa
et al.. Caspase induction and BCL2 inhibition in human adipose tissue: a potential
á
relationship with insulin signaling alteration.Diabetes Care. 2013 Mar;36(3):513-21.

• Murri M, leiVa i, GóMez-zuMaquero JM, tinahones FJ, carDona F, soriGuer F et al.. Gut
microbiota in children with type 1 diabetes differs from that in healthy children: a í

case-control study.BMC Med. 2013 Feb 21;11:46.

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During 2013 the research group has received founding from Instituto de Sa- í
Highlights
lud Carlos III for 5 projects, PI13/02628, two associated to Miguel Servet
type I (CP13/00065 and CP13/00188), two associated to Miguel Servet type

II (CPII/13/0041, CP13/0023) and 3 grants from Servicio Andaluz de Salud

(PI0173/2013 , PI0153/2013 and PI557/2013 ). We have developing 17 clinical
trials supported by private companies, with a total budget of € 697,144.74. We

have published 31papers in first quartile, 12 of them in the first decile.

We have got different awards: one to the best paper presented within the Basic
Endocrinology category at the 38th Congress of the Andalusian Society of Endo-

crinology and Nutrition. Cadiz , 7-9 November 2013 : Coin Aragüez Leticia , Rajaa

El Bekay , Diego Garcia Fernandez , Wilfredo Olivera Oliva , Rosa López Bernal ,
Mercedes Clemente Postigo , Javier Delgado list , Alberto Ruiz Diaz , Rocio Ruiz

Guzman , Rafael Martnez Vzquez , Vendrell Joan , Malagon Maria del Mar, Fran-

cisco Jos Tinahones Madueo (Effects of GLP-1 on the differentiation of human
adipocyte metabolism) and another on Vascular Risk Factors from SEEN Foun-

dation, Granada, May 2013 (Hemoglobin A1C versus oral glucose tolerance test 13
0
in postpartum diabets screening). Maria Jose Picon, Mora Murri, Araceli Muñoz, 2
Jos Carlos Fernndez- Garca, Ricardo Gomez- Huelgas, Francisco J. Tinahones, RT
PO
published in Diabetes Care, August 2012;1648-1653 .
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In addition, our UGC has received in 2013 the award for whole career granted by AL
SEEN
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