Page 107 - MemoriaOBN-Eng

www.ciberobn.es

• GONADAL FACTORS AND OBESITY. We study the metabolic alterations associated to
gonadal and reproductive dysfunction, with special attention to the analysis of the

influence of nutritional and gonadal factors in the generation of obesity, as studies
by the use of preclinical models of sequential obesogenic insults

• OBESITY AND CANCER. We aim to evaluate the alterations induced by obesity in the

generation and progression of hormone-dependent cancers, such as breast, ovarian
and prostate cancers, using both human samples and suitable animal models, with spe-

cial attention to the analysis of neuroendocrine metabolic and inflammatory markers.

• sanGiao-alVarellos s, ManFreDi-lozano M, ruíz-Pino F, naVarro VM, sánchez-GarriDo Ma,
Most relevant
leon s et al.. Changes in Hypothalamic Expression of the Lin28/let-7 System and Re-
scientific lated MicroRNAs During Postnatal Maturation and After Experimental Manipulations

articles
of Puberty.Endocrinology. 2013 Feb;154(2):942-55.
áó
• snchez-GarriDo Ma, castellano JM, ruíz-Pino F, García-Galiano D, ManFreDi-lozano M,
l s .. Metabolic programming of puberty: sexually dimorphic responses to
eonet al
early nutritional challenges.Endocrinology. 2013 Sep;154(9):3387-400.

• alMaBouaDa F, Diaz-ruíz a, raBanal-ruíz y, PeinaDo Jr, Vazquez-Martínez r, MalaGon MM.
Adiponectin receptors form homomers and heteromers exhibiting distinct ligand bin-
á
ding and intracellular signaling properties.J Biol Chem. 2013 Feb 1;288(5):3112-25.
óñ

• crDoBa-chacn J, Gahete MD, Pozo-salas ai, castaño JP, KineMan rD, luque rM. Endo-

genous somatostatin is critical in regulating the acute effects of L-arginine on growth
hormone and insulin release in mice.Endocrinology. 2013 Jul;154(7):2393-8.

• l rM, i-c a, l-s lM, J-r l, V-M e, G
uqueBezostaóPezáncheziMénezeinaeneGasorenoálVez
Ma et al.. A cellular and molecular basis for the selective desmopressin-induced
ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential

therapeutic implications.J Clin Endocrinol Metab. 2013 Oct;98(10):4160-9.

The research activities carried out by our multidisciplinary team during 2013 have
Highlights
allowed us to advance towards the completion of our major scientific goals. In detail:
1. We have implemented proteomic analyses of the adipose tissue (AT) aiming at the iden-

tification of novel molecular targets altered in human AT, deregulated in conditions of obe-
sity and insulin resistance; studies that have been carried out in collaboration with various

clinical groups of CIBER.
2. We have completed studies directed towards the characterization of the receptors and

signaling routes of adiponectin, as key metabolic signal derived from the AT, involved in the
control of insulin sensitivity and whole body metabolism.

3.Mainly though international collaborations, we have carried out a series of studies on the

neuroendocrine alterations seen in preclinical models of obesity and other forms of metabo-
lic stress; studies that include the analysis of key signals of the somatotropic (and related)
axis, such as GH, ghrelin, IGF-1 and insulin.

4. We have published studies in preclinical models concerning the analysis of the impact of 13
0
early obesogenic insults on pubertal timing in both sexes. In addition, we have also comple- 2
ted a first series of analyses on the role of microRNAs in the central (hypothalamic) control RT
PO
of puberty, and its modulation by different (early) regulators, including the nutritional state E
during the postnatal life.
R
AL
5. We have advanced towards the characterization of the hypogonadal state frequently U
linked to obesity, using preclinical (rodent) models of exposure to different obesogenic in- NN
A
sults; these studies have also permitted us to elucidate some of the mechanisms involved /
in this phenomenon.
BN
O
6. We have continued studies aiming to define the neuroendocrine factors whereby obe- ER
sity and some endocrine-dependent tumors, such as breast cancer, are associated. In the B
CI
same vein, we have published data on novel diagnostic approaches to identify some types
of tumors of considerable metabolic relevance, such as pituitary corticotropinomas causing 107

Cushing syndrome.