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• e r, r e, s-s J, c Mi, D P, c D .. Primary Pre-
Most relevant struchosalasalVaDóoVasharMorellaet al
vention of Cardiovascular Disease with a Mediterranean Diet.N Engl J Med. 2013
scientific Feb 25;.

articles
• corella D, carrasco P, sorlí JV, estruch r, rico-sanz J, Martínez-González Ma et al..
Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymor-

phism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled
trial in a high-cardiovascular-risk population.Diabetes Care. 2013 Aug 13;.

• s-P M, G M, V s J, P o, G-s P, i G J
otosrietouillénicenteorliortolésuilleMaizGnacioonzález
et al.. Relevant associations of the glucokinase regulatory protein/glucokinase gene
variation with TAG concentrations in a high-cardiovascular risk population: modula-

tion by the Mediterranean diet.Br J Nutr. 2013 Jan 28;109(2):193-201.

• sotos-Prieto M, Guillén M, Portolés o, sorlí JV, González Ji, asensio eM et al.. Asso-
ciation between the rs6950982 polymorphism near the SERPINE1 gene and blood

pressure and lipid parameters in a high-cardiovascular-risk population: interaction

with Mediterranean diet.Genes Nutr. 2013 Jul;8(4):401-9.

• sMith ce, tucKer Kl, arnett DK, noel se, corella D, BorecKi iB et al.. Apolipoprotein
A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2

U.S. populations.J Nutr. 2013 Dec;143(12):1865-71.

Our research group has participated since 2003 in the recruitment and follow-up
Highlights
of participants in the PREDIMED study. It has been the group that have recruited
the highest number of patients (n = 1094) and our work has been crucial for the

success of the PREDIMED study. So, in 2013 we highlight as the most important

publication, that carried out in the NEJM, that showed the protective effects of the
Mediterranean diet in the Prevention of Cardiovascular Diseases.

In parallel, our group is a pioneer group in the study of gene-diet interactions in

the genomic epidemiology of obesity and cardiovascular diseases. During 2013 we

have continued to achieve interesting results on gene-diet interactions in both the
Spanish population and U.S. populations in collaboration with Dr. JM . Ordovás,

Boston . We also note that in the PREDIMED population we have published the first
gene-diet interaction (Corella et al, Diabetes Care 2013) in which, using a rando-

mized dietary intervention, we have demonstrated that the Mediterranean diet

counteracts the increased risk of cerebrovascular disease conferred by a genetic
polymorphism in the TCF7L2 gene. This study is very relevant in nutrigenetics, as it

is the first time in the world that it has been demonstrated that a dietary interven-

tion may modulate the risk of cardiovascular disease in genetically susceptible in-
dividuals and undoubtedly contribute to the advancement of personalized nutrition.

Our group has been involved in several guidelines, conducting clinical trials and

Theses and has had a significant presence in both media as digital and print media
programs as well as a TV (RTVE) magazine.
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