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• Characterization of Fetuin -A and Musclin / Osteocrin as new peripheral signals

involved in energy homeostasis.

• Study of the role of hormone irisin as a new target for the treatment of obesity

and type 2 diabetes.

• Study of the physiological mechanisms responsible for the regulation of energy

balance in the gastrointestinal tract. Role of ghrelin nesfatin a -1 , gastricen-
dogenous cannabinoid, signaling pathway activated by FNDC5 andmTOR/S6k1.

• Study of the effect of lactation on metabolism. Study of lipid metabolism in adi-

pose tissue and gastrointestinal mechanisms.

• s ll, a-M o, F c, c c, P M, B-F s .. The
Most relevant eninlassaDiolGueiraastelaoarDoarJaernánDezet al
Gastric CB1 Receptor Modulates Ghrelin Production through the mTOR Pathway to
scientific Regulate Food Intake.PLoS One. 2013 Nov 26;8(11):e80339.

articles
• anDraDe s, Pinho F, riBeiro aM, carreira M, casanueVa FF, roy P et al.. Immunization
against active ghrelin using virus-like particles for obesity treatment.Curr Pharm

Des. 2013;19(36):6551-8.

• roca-riVaDa a, castelao c, senin ll, lanDroVe Mo, Baltar J, Belén cruJeiras a et al.. FNDC5/
irisin is not only a myokine but also an adipokine.PLoS One. 2013;8(4):e60563.
í
• s-z i, l M, G-r u, B-l M, M cs, c
antosasoDeirourriaránoDríGuezouzoorenzoosteiroasanueVa
FF et al.. β-Arrestin signal complex plays a critical role in adipose differentiation.Int
J Biochem Cell Biol. 2013 Jul;45(7):1281-92.

• c aB, D-l a, c Mc, a M, c FF. Oxidative stress
ruJeirasazaGaresarreiraMilasanueVa
associated to dysfunctional adipose tissue: a potential link between obesity, type 2
diabetes mellitus and breast cancer.Free Radic Res. 2013 Apr;47(4):243-56.

Highlights
During 2013, the Molecular Endocrinology group has focused its efforts on de-
veloping new lines of work in order to strengthen its research on new aspects of

obesity from basic character and, especially, applied to increase their capacity and
methodological resources. In this regard, two novel approaches for therapeutic

treatment of obesity based on nutritional supplements, and in the field of nanote-

chnology applied to metabolic control are remarkable.

Molecular Endocrinology group has developed an extensive research activity that
has as one of its central themes, the study of the newly discovered irisin and its

relationship with obesity resulting in identify in got as anadipokine and numerous

articles published in 2013 or will be published shortly.

Also it has obtained new research projects among which is remark able the call for
Proyectos Integrados de Excelencia en los Institutos de Investigacion Acreditados
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del ISCIII.
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