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• r-P a, V MJ, G-t D, F c, s KP, a-c
Most relevant oMeroicóázquezonzálezouceDaolGueiraKiBicKalVarezresPo
M et al.. Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin.
scientific Neuropsychopharmacology. 2013 Jan 24;.

articles
• iMBernon M, Beiroa D, Vázquez MJ, MorGan Da, Veyrat-DureBex c, Porteiro B et al.. Cen-
tral Melanin-Concentrating Hormone Influences Liver and Adipose Metabolism Via

Specific Hypothalamic Nuclei and Efferent Autonomic/JNK1 Pathways.Gastroentero-
logy. 2013 Mar;144(3):636-649.e6.

• M-M M, n r, F s, s V, a-M o, D c ..
enachoárquezoGueirasaBBianoauzeaulassaDiiéGuezet al
Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in diver-
gent effects on metabolic syndrome and obesity depending on diet.Cell Metab. 2013

Aug 6;18(2):199-211.

• lóPez M, alVarez cV, noGueiras r, DiéGuez c. Energy balance regulation by thyroid hor-
mones at central level.Trends Mol Med. 2013 Jul;19(7):418-27.
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• -c M, M-s n, r-P F, G-l M, a cV, t-
lVarezresPoartínezánchezuízinoarcíaaVanDeiralVarezena
seMPere M et al.. The orexigenic effect of orexin-A revisited: dependence of an intact

growth hormone axis.Endocrinology. 2013 Oct;154(10):3589-98.

The major focus of its research is trying to uncover new mechanisms involved
Highlights
in weight gain in order to develop new drug targets for obesity. In addittion new

precilinical animal models , including GMA, are being set up.
The grupo is structured in different research áreas led by different PIs. No-

teworthy some of them are being funded by the ERC through its Startin Grants

(R.Nogueiras) and Consolidated Grants (M.Lopez) programmes. In addittion we
are currently part of two projects founded by the VII PM of the EU. Over the last

4 years the group have generated 4 patents and published more tan 100 papers

in journals scuh as Cell, Nat Medicine, Cell Metabolism, Physiol Rev, Diabetes
etc. Over the last three years 10 members of the gropu presented their Ph.D

and over the last few years scientists from 8 different countries undertook their

training in our group.

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