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• e r, r e, s-s J, c Mi, D P, c D .. Primary Pre-
Most relevant struchosalasalVaDóoVasharMorellaet al
vention of Cardiovascular Disease with a Mediterranean Diet.N Engl J Med. 2013
scientific Feb 25;.

articles
• corella D, carrasco P, sorlí JV, estruch r, rico-sanz J, Martínez-González Ma et al..
Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymor-

phism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled
trial in a high-cardiovascular-risk population.Diabetes Care. 2013 Aug 13;.

• a s, V-M P, c-B G, c r, u-s M, l-r
rranzalDerasartínezhiValanchasasrPiarDaaMuelaaVentós
rM et al.. Cardioprotective effects of cocoa: clinical evidence from randomized clini-
cal intervention trials in humans.Mol Nutr Food Res. 2013 Jun;57(6):936-47.

• c-B G, a s, l-r rM, e r. Effects of wine, alcohol and
hiValanchrranzaMuelaaVentósstruch
polyphenols on cardiovascular disease risk factors: evidences from human studies.
Alcohol Alcohol. 2013 May-Jun;48(3):270-7.

• e r, s-s J. “Towards an even healthier Mediterranean diet”. Nutr Me- ó
struchalasalVaDó
tab Cardiovasc Dis. 2013 Dec;23(12):1163-6.

In the last years, this group has received grants from the National Institute of
Highlights
Health (NIH) from USA, CICYT, Instituto Nacional de Investigación Agroalimen-
taria (INIA) del Ministerio de Economía y Competitividad, and Fondo de Investi-

gacin Sanitaria (FIS)

In 1985, we started to study the toxic effect of alcohol on cardiovascular (N
Engl J Med 1989, Ann Intern Med 1994; JAMA 1995, Arch Inter Med 1995)

and central nervous systems (Arch Neurol.1995; Ann Neurol.1997). At 1994, a

new research program on effects of key foods on atherosclerosis started. First,
we analyzed the effects of alcoholic beverages on adhesion molecules related

with the development of atherosclerosis (Alcohol Clin Exp Res 1998 and 1999;

Thromb Haemost 2002) and the effects of wine and beer on inflammatory mar-
kers related to atherosclerosis (Atherosclerosis 2004 and 2014, Am J Clin Nutr

2004) and oxidative stress parameters (Nutr Metab Cardiovasc Dis. 2010). Fi-
nally, two new biomarkers of wine and beer intake have been developed (Br J

Nutr. 2014 and J Nutr. 2014).

In addition, Prof. Estruch is the leader of the Thematic Network “Mediterranean

Diet and Cardiovascular Disease” from the ISCIII (Spain). In 2003, we started
an ambitious study (PREDIMED) to evaluate the effects of Mediterranean Diet

and its main components on the primary prevention of cardiovascular disease in

high-risk patients, which have enrolled near 7.500 patients. The study finished
at the end of 2011 and their main results have been published in top journals,

including N Engl J Med (2013), JAMA (2014), Ann Intern Med (2006 and 2014),
Arch Intern Med (2007 and 2008), Am J Clin Nutr (2009), J Nutr (2010), Diabe-
13
tes Care (2011), PloS One (2012), Eur J Heart Fail (2014), Int J Cardiol (2014) 0
2
and Arterioscler Thromb Vasc Biol (2014). The group has published more than RT
250 manuscripts in peer-review Journals.
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