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• c-D a, c Me, P o, s-w J, P G, l M
Most relevant anFranuqueasaDoastoránchezanDelMerDe la enaerMaet
al.. Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.J Lipid
scientific Res. 2012 Nov 21;.

articles
• DaiMiel la, FernánDez-suárez Me, roDríGuez-aceBes s, cresPo l, lasunción Ma, GóMez-co-
ronaDo D et al.. Promoter analysis of the 3β-hydroxysterol Δ24-reductase (DHCR24)

gene: characterization of sterol regulatory element-binding protein (SREBP)-media-
ted activation.Biosci Rep. 2012 Oct 10;.

• c Me, P o, M P, c-D a, M-B J, K FB ..
asaDoastorariscalanFránuqueartínezotasraeMeret al
Hormone-sensitive lipase deficiency disturbs the fatty acid composition of mouse
testis.Prostaglandins Leukot Essent Fatty Acids. 2013 Jan 28;.

• B-c Ji, c c, G e, V B, a F, c a .. Role
otellaarreteroarrerouerraalBuenarrietaalañaset al
of Peripherally Inserted Central Catheters in Home Parenteral Nutrition: A 5-Year
Prospective Study.JPEN J Parenter Enteral Nutr. 2012 Aug 16;.
á
• V c, B-c Ji, c D, F M, l M, l e .. White fish
zquezotellaarreteroorellaiolaGeurBeet al
reduces cardiovascular risk factors in patients with metabolic syndrome: The WISH-

CARE study, a multicenter randomized clinical trial.Nutr Metab Cardiovasc Dis. 2013
Nov 1;.

We previously demonstrated that several amphiphilic drugs, included the selective
Highlights
estrogen-receptor modulators and antipsychotics, inhibit cholesterol biosynthesis.

More recently, we showed that both first and second generation antipsychotics also
affect the intracellular lipid traffic, which secondarily induces fatty acid biosynthesis

and the secretion of apo B and triglyceride. These effects may explain dyslipidemia
and obesity often found in patients treated with antipsychotics. Moreover, SERMs

upregulate LDL receptor in primary human lymphocytes. DHCR24 catalyses the

reduction of the C-24 double bond of sterols during cholesterol biosynthesis and
has been involved in cell growth, senescence and cellular response to oncogenic

and oxidative stress. We elucidated the mechanism of DHCR24 gene regulation

by cholesterol availability and identified other putative cis-acting elements which
may be relevant for the regulation of DHCR24 expression. Male hypogonadism

has been linked to obesity and diabetes. Recent work from our group shows that
bariatric surgery is accompanied by the increase of circulating testosterone in

parallel with an improvement in insulin sensitivity. In testes from mice lacking

hormone sensitive lipase (HSL-/ -), which have impaired spermatogenesis, we
found profound alterations in both the sterol content and the fatty acid profile as

well as increased expression of HDL receptor SR-BI, changes that may explain the

infertility of these mice. Reduction of cardiovascular risk with high consumption
of fish in diet is still a matter of debate due to concerns raised from heavy metal

contamination. In a multicenter randomized crossover clinical trial including 273
individuals with metabolic syndrome, we found that regular consumption of hake 13
0
significantly increased serum EPA and DHA and decreased LDL cholesterol concen- 2
RT
trations, which was accompanied by a reduction in waist circumference and blood PO
pressure. These findings demonstrate the beneficial effect of white fish consump- E
R
tion in the reduction of cardiovascular risk in patients with metabolic syndrome.
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