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• e r, r e, s-s J, c Mi, D P, c D .. Primary Preven-
struchosalasalVaDóoVasharMorellaet alMost relevant
tion of Cardiovascular Disease with a Mediterranean Diet.N Engl J Med. 2013 Feb 25;.
scientific
• Bes-rastrollo M, schulze MB, ruíz-canela M, Martínez-González Ma. Financial conflicts
articles
of interest and reporting bias regarding the association between sugar-sweetened
beverages and weight gain: a systematic review of systematic reviews.PLoS Med.

2013 Dec;10(12):e1001578; dicsussion e1001578.

• corella D, carrasco P, sorlí JV, estruch r, rico-sanz J, Martínez-González Ma et al..
Mediterranean Diet Reduces the Adverse Effect of the TCF7L2-rs7903146 Polymor-

phism on Cardiovascular Risk Factors and Stroke Incidence: A randomized controlled
trial in a high-cardiovascular-risk population.Diabetes Care. 2013 Aug 13;.

• s-V a, M-G Ma, e r, s-s J, c D, c
ánchezilleGasartínezonzálezstruchalasalVaDóorellaoVas
Mi et al.. Mediterranean dietary pattern and depression: the PREDIMED randomized
trial.BMC Med. 2013 Sep 20;11:208.

• t e, h FB, e r, B-c P, c D, s-s J .. Effect of
oleDoustruchuilosialesorellaalasalVaDóet al
the Mediterranean diet on blood pressure in the PREDIMED trial: results from a ran-

domized controlled trial.BMC Med. 2013 Sep 19;11:207.

In 2013, the main results derived from the PREDIMED trial (2003-2013) have
Highlights
been reported in the New England Journal of Medicine. In the frame of this study,

our group has also evaluated the effect of the nutritional intervention on blood
pressure and the association between alcohol consumption and depression. Mo-

reover, a new international project aiming to analyze the metabolic profile of the
PREDIMED participants was initiated. The objectives of this project are to observe

if the intervention changed the metabolic profile of the participants, to assess if

changes in the metabolic profile mediated the effects of the intervention on the
cardiovascular events and to evaluate a potential effect modification of the inter-

vention depending on the baseline metabolic profile of each subject. In addition,

in 2013 a project funded by the regional Government of Navarra was completed.
This latter project aimed to assess the effect of the intervention of the PREDIMED

trial on the cognitive function of the participants.

On the other hand, during 2013, the PREDIMED Plus pilot study was performed
and the results analyzed.

Regarding the SUN cohort, results on the association between lifestyle factors

and chronic diseases have been published, supported by national and regional

founding sources. Thus, we have found an association between fried foods or
sweetened carbonated beverages and metabolic syndrome, and between alcoho-

lic beverages and depression or total mortality.

Collaborations with other groups have led to the publication of two papers about a
novel index, the lipophilic index, and its association with coronary heart disease.
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