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RESEARCH GROUPS
Endocrinology and metabolism
Programme: P1
Lead Researcher: Álvarez Escolá, Carmen Group members
STAFF MEMBERS: Fernández Millán, Elisa ASSOCIATED MEMBERS: Escrivá Pons, Fernando | Lizarraga Mollinedo, Esther | Martín Arribas, Ma Ángeles
Main lines of research
The identification of the cellular and molecular mechanisms that link poor perinatal growth and increased risk of metabolic syndrome and type 2 diabetes in adult life through the use of animal models of nutritional manipulation: maternal undernutrition followed or not by overnutrition . To this end we have focused on:
• • • • • • •
The effect of nutrients on the growth, death and function of pancreatic alfa and beta cells: involve- ment of different growth factors .
The potential role of incretins (GLP-1 and GIP) in the relationship between intrauterine growth restric- tion and the development of type 2 diabetes in adulthood: study of the entero-insular axis .
Involvement of autophagy in the ineffective macromolecule turnover in IUGR individuals, which favors insulin resistance development .
Changes in insulin/glucagon plasma levels and liver sensitivity associated with early undernutrition which could alter the available substrates for the growing brain .
Impact of early undernutrition on the insulin and leptin hypothalamic responses and the hypothalamic expression of orexigenic and anorexigenic factors (NPY, POMC) .
The effect of early undernutrition followed by an overcaloric diet on the obesity risk and the white adipose tissue metabolism .
Study of the ectopic lipid deposits in the skeletal muscle and liver consequence of nutritional rehabili- tation .
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CIBERDEM » Annual report 2014