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Most relevant scientific articles
• Hurtado-Carneiro V., ronCero i., eGGer s.s., WenGer r.H., Blázquez e., sanz C. et al . PAS Kinase Is a Nutrient and Energy Sensor in Hypothalamic Areas Required for the Normal Function of AMPK and mTOR/S6K1 . Molecular Neurobiology . 2014;50(2):314-326 .
Highlights
Institution: Universidad Complutense de Madrid Contact: Facultad de Farmacia · Ciudad Universitaria, S/N. 28040 Madrid Phone: (+34) 91 394 14 43 · E.mail: [email protected]
During 2014 the following activities were carried out:
• Veronica Hurtado presented the Doctoral Thesis entitled: “Metabolic sensors in the brain. Intercom- munication with the regulatory peptides of food intake” . Directors: E . Alvarez and M . C . Sanz .
• Yannick Le Baud performed the Master Thesis Work in Human Nutrition and Applied Dietetics entitled: “Study of the molecular mechanisms involved in the effect of glucose on proliferation of cultured rat astrocytes . Effect of insulin and GLP-2 . “ . Tutors: J .M . Ruiz-Albusac and E . Velázquez .
• Pilar Dongil and Ana Pérez performed the Master Thesis Works in Research in Biomedical Sciences entitled: “Role of PASK in oxidative metabolism and mitochondrial function . Characterisation of re- gulators of mitochondrial biogenesis in control and deficient PASK MEFs“ and “Effects of PASK on the proliferation and apoptosis processes, and on the control of the cell cycle in control and deficient MEFs PASK”, respectively . Tutors: E . Alvarez and M . C . Sanz .
Likewise, we have initiated the study of interactions between diseases such as type 2 diabetes (T2DM) and Alzheimer’s (AD), considered as the two major epidemics of the XXI century . By analyzing the resistance to insulin action, we want to know if this resistance is present in both disease entities and if such resistance is manifested centrally, peripherally or in both forms . In samples from different areas of healthy human brain used as control, from AD, AD + T2DM and T2DM of different ages, we study the insulin signal transduction pathway which is initiated by the phosphorylation of its own receptor, and rendering particular attention in the identification of phosphorylated residues of tyrosine and serine/ threonine of the IRS-1 and of other mediators . Finally, in mice with overexpression of tau protein is studying the central and peripheral resistance to insulin .
This work was supported by a grant from the Mutua Madrileña Foundation .
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