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RESEARCH GROUPS
Transgenic Animal Models
and Gene Therapy Approaches for Diabetes
Programme: P3
Lead Researcher: Bosch Tubert, Fàtima Group members
STAFF MEMBERS: Casellas Comallonga, Alba
ASSOCIATED MEMBERS: Barrero Victorio, Jennifer | Carretero Romay, Ana | Elias Puigdomenech, Ivet | Ferre Masferrer, María del Tura | Franckhauser, Sylvie | García Martínez, Miguel | Haurigot, Virginia | Jiménez Cenzano, Verónica | Mallol Domínguez, Cristina | Melgarejo Bermúdez, Verònica | Molas Laplana, María | Moya Martínez, Marta | Muñoz Forero, Sergio Antonio | Nacher García, Víctor | Navarro Beltrán, Marcos | Otaegui Goya, Pedro José | Pujol Altarriba, Anna | Riu Pastor, Efrén | Roca Lecha, Carles | Ruberte Paris, Jesús | Villacampa Alcubierre, Pilar | Zaguirre Sánchez, Mireia
Main lines of research
• Study of causes and pathophysiological mechanisms of diabetes and obesity . - Study of the role of pancreatic ß cell alterations in the development of diabetes . - Identification of novel genes in adipose tissue involved in the development of diabetes and obesity . - Identification of novel mechanisms involved in browning of white adipose tissue .
• Development of new gene therapy approaches for diabetes . - Gene therapy approaches for the treatment of type 1 diabetes centered on genetic engineering of skeletal
muscle to produce insulin and/or increase glucose uptake .
- Gene therapy approaches for type 2 diabetes and obesity centered on genetic engineering of skeletal muscle and/or the liver .
- Study of in vivo pancreas regeneration in diabetic animals: Regeneration of endocrine pancreas by IGF-1 Betasel: in vivo selection of genes to improve beta cell mass
- Development of new approaches for type 2 diabetes and obesity centered on genetic engineering of adipose tissue .
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CIBERDEM » Annual report 2014