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Most relevant scientific articles
• silVestre-roiG C., Fernández P., manseGo m.l., Van tiel C.m., Viana r., anselmi C.V. et al . Genetic variants in CCNB1 associated with differential gene transcription and risk of coronary in-stent restenosis . Cir- culation: Cardiovascular Genetics . 2014;7(1):59-70 .
• esmatJes e., Jansa m., roCa d., Pérez-Ferre n., del Valle l., martínez-HerVás s. et al . The efficiency of telemedicine to optimize metabolic control in patients with type 1 diabetes mellitus: Telemed study . Diabetes Technology and Therapeutics . 2014;16(7):435-441 .
• martínez-HerVás s., Vinue a., nunez l., andres-BlasCo i., Piqueras l., tomás real J. et al . Insulin resistance aggravates atherosclerosis by reducing vascular smoothmuscle cell survival and increasing CX3CL1/ CX3CR1 axis . Cardiovascular Research . 2014;103(2):324-336 .
• Cortes r., martínez-HerVás s., iVorra C., de marCo G., González-alBert V., roJo-martínez G. et al . Enhan- ced reduction in oxidative stress and altered glutathione and thioredoxin system response to unsa- turated fatty acid load in familial hypercholesterolemia . Clinical Biochemistry . 2014;47(18):291-297 .
• Valdes s., maldonado-araque C., GarCía-torres F., GodaY a., BosCH-Comas a., Bordiu e. et al . Ambient temperature and prevalence of obesity in the spanish population: The di@bet .es study . Obesity . 2014;22(11):2328-2332 .
Highlights
Institution: Fundación para la Investigación del Hospital Clínico de la Comunidad Valenciana (Fundación INCLIVA) Contact: Instituto de Investigación Sanitaria INCLIVA · Av. Blasco Ibáñez, 17. 46010 Valencia Phone: (+34) 96 197 35 36 · E.mail: [email protected] · Website: http://www.incliva.es
The effects of insulin resistance (IR) on unstable atheromatous plaques were studied in a mouse model of IR-Metabolic Syndrome (MS) and in human subjects with and without IR-MS . The expression of main inflammatory mediators implicated in plaque vulnerability was measured . Results: IR promotes plaque vulnerability due to augmented inflammatory pathway expression .
We studied, in 14 patients with Familial Hypercholesterolemia (FH) and 20 controls, the response to an unsaturated oral fat load test (OFLT) analyzing the mRNA levels of genes involved in antioxidant systems . Results: An OFLT with predominantly unsaturated fat has a different effect on postprandial antioxidant enzymes mRNA levels in controls than in FH patients . Increased antioxidant enzymes mRNA does not reduce postprandial oxidative stress in FH . This could influence dietary patterns in FH .
The associations between ambient temperature and obesity in the Spanish population using an ecological focus was examined with data from the Di@bet .es study . The prevalence rates of obesity in different geographical areas, divided according to mean annual temperature quartiles, were 26 .9% in quartile 1 (10 .4-14 .5°C) and 33 .6% in quartile 4 (17 .8-21 .3°C) (P?=?0 .003) .
Diagnostic tools to assess restenosis risk after stent deployment are important in diabetic patients . The CCNB1 gene regulates cell proliferation, a key component of in-stent restenosis . Results: 3 SNP’s in CCNB1 were associated with increased restenosis risk in 1000 patients (36 .4% diabetics) undergoing coronary stent placement . These findings could provide diagnostic tools in risk stratification for restenosis .
Impact of an Internet-based telematic system on the management of patients with type 1 diabetes, >18 years old and with a HbA1c >8% . Intervention group (two visits and five telematic appointments) vs . control group (seven visits) . Five different variables were studied . Results: interactive telematic appointments in subjects with type 1 diabetes and inadequate metabolic control is an efficient strategy, providing results comparable to those of face-to-face appointments .
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