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Most relevant scientific articles
• Pasquali l., Gaulton k.J., rodríGuez-seGui s.a., mularoni l., miGuel-esCalada i., akerman i. et al . Pan- creatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants . Nature Genetics . 2014;46(2):136-143 .
• sHaW-smitH C., de FranCo e., allen H.l., Batlle m., FlanaGan s.e., BoroWieC m. et al . GATA4 mutations are a cause of neonatal and childhood-onset diabetes . Diabetes . 2014;63(8):2888-2894 .
• rodriGo-torres d., aFFo s., Coll m., morales-iBánez o., millán C., BlaYa d. et al . The biliary epithelium gives rise to liver progenitor cells . Hepatology . 2014 .
• tHorens B., tarussio d., maestro m.a., roVira m., Heikkila e., Ferrer J . Ins1Cre knock-in mice for beta cell- specific gene recombination . Diabetologia . 2014 .
• Weedon m.n., CeBola i., PatCH a.-m., FlanaGan s.e., de FranCo e., CasWell r. et al . Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis . Nature Genetics . 2014;46(1):61-64 .
Highlights
During 2014 the team has achieved several scientific goals, including the generation of epigenomic reference maps in embryonic and adult pancreatic islets, the discovery of novel Mendelian and polygenics variants that disrupt pancreatic enhancers and thereby contribute to diabetes mellitus, and the identification of long non-coding RNAs that control pancreatic beta cell regulatory networks . We have characterized a conditional mouse mutation of a chromatin regulator that is a potential molecular target to reprogram pancreatic beta cells from pancreatic exocrine cells . We are furthermore completing a study that will determine how allelic variation influences genome activity in pancreatic islets .
In addition to ongoing EU and national grants, the team has gained a new grant from Novonordisk Foundation that will support the generation of a new KO mouse model and a postdoctoral fellowship salary for 3 years . We have also obtained an EU Marie Curie Training Network that has just started . The team has recruited a new postdoctoral trainee who gained her own Marie Curie award . One of the postdoctoral trainees of the lab, Dr Lorenzo Pasquali, has obtained a Ramon y Cajal award and has been offered a Prinicipal Investigator position in Fundacio Joan Carreras/IMPPC .
Institution: Instituto de Investigaciones Biomédicas August Pi i Sunyer Contact: Centro Esther Koplowitz · C/ Rosselló, 149. 08036 Barcelona · Phone: (+34) 93 227 30 28 E.mail: [email protected] · Website: http://betacellregulation.net
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