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RESEARCH GROUPS
Mechanisms of Control of Glucose
and Fatty Acid Metabolism in Skeletal
Muscle Cells and Metabolic Impairment in Atrophy
Programme: P4
Lead Researcher: Gómez Foix, Anna Maria Group members
STAFF MEMBERS: Montori Grau, Marta ASSOCIATED MEMBERS: García Martínez, Celia | Orozco, Anna | Osorio Conles, Óscar
Main lines of research
• Mechanisms of control of skeletal muscle glycogen metabolism: differential functionality of the pro- tein phosphatase 1 glycogen-associated regulatory subunits and function of GNIP1 (glycogenin Inte- racting Protein 1) / TRIM7 .
• Participation and identity of signaling molecules derived from palmitate metabolism in the impairment of muscle cell insulin response and induction of an inflammatory signal . Metabolic control by the fatty acid transport protein 1 (FATP1) in the context of high-fat diet induced diabetes .
• Role of secretable proteins predominant in adipose tissue and muscle, such as PTX3, CCDC80 or colla- gen VI, in the modulation of insulin signaling and glucose metabolism in adipocytes and muscle cells .
• Development of an electroporator device directly applicable to adherent cells cultured on standard multiwell plates to facilitate molecular transfer .
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CIBERDEM » Annual report 2014