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Most relevant scientific articles
• Ceriello a., noVials a., CaniVell s., la sala l., PuJadas G., esPosito k. et al . Simultaneous GLP-1 and insulin administration acutely enhances their vasodilatory, antiinflammatory, and antioxidant action in type 2 diabetes . Diabetes Care . 2014;37(7):1938-1943 .
• CadaVez l., montane J., alCarraz-Vizan G., Visa m., Vidal-FaBreGa l., serVitJa J.-m. et al . Chaperones ame- liorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression . PLoS ONE . 2014;9(7) .
• la sala l., PuJadas G., de niGris V., CaniVell s., noVials a., GenoVese s. et al . Oscillating glucose and constant high glucose induce endoglin expression in endothelial cells: the role of oxidative stress . Acta Diabetologica . 2014 .
• tom r.z., GarCia-roVes P.m., sJoGren r.J.o., JianG l.q., Holmstrom m.H., desHmukH a.s. et al . Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice . Diabetes . 2014;63(5):1560-1571 .
• Ceriello a., noVials a., orteGa e., PuJadas G., la sala l., testa r. et al . Hyperglycemia following recovery from hypoglycemia worsens endothelial damage and thrombosis activation in type 1 diabetes and in healthy controls . Nutrition, Metabolism and Cardiovascular Diseases . 2014;24(2):116-123 .
Highlights
Institution: Instituto de Investigaciones Biomédicas August Pi i Sunyer Contact: Centro Esther Koplowitz · C/ Rosselló, 149. 08036 Barcelona Tel.: (+34) 93 227 54 00 (ext. 4153) · E.mail: [email protected] Website: http://www .diabetes-obesity-research .org
Among the overall results of our scientific productivity during 2014, we highlight publications in high- impact journals in our field, both in basic and clinical research, with special mention of our findings on: the effect of GLP-1 on endothelial function in patients with diabetes; the protective effect of chaperones on the response of the pancreatic beta-cell to endoplasmic reticulum stress under conditions of glucolipotoxicity; and the effect of AMPK activation on insulin sensitivity in obese leptin-deficient ob/ob mice .
Over the past year our group has received grants from different funding sources: Health Research Fund (FIS) grant from the Instituto de Salud Carlos III; Research Group Support (SGR) grant from the Government of Catalonia; a prestigious international grant from the European Foundation for the Study of Diabetes (EFSD) for investigating microRNAs involved in the pathogenesis of diabetes . The previous year, our group entered a 3-year collaborative agreement with Grífols company to study the potential of one of its pharmaceutical products for treating diabetes, as well as an agreement with Novartis for studying microRNAs as prediabetes biomarkers .
Two doctoral theses were defended in 2014, the results of which have been published in the same year and also the current one .
In collaboration with the Spanish Diabetes Society (SED), our group organized a theoretical/practical course on translation diabetes research, aimed at resident endocrinologists .
Finally, in terms of social outreach activities, the clinician group members have presented several educational sessions open to the public on the importance of lifestyle in achieving good diabetes control .
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