Page 22 - MEMOCiberehd014-ENG

P2. VIRAL HEPATITIS
Coordinator:
Dr. Juan Ignacio Esteban Mur
Associate Coordinators: Drs. Xavier Forns and Manuel Romero Gómez
Area 2 includes 8 research groups led by Dr . Juan Ignacio Esteban Mur (Hospital Universitari Vall d’Hebron . Barcelona), Dr . Rafael Esteban (Hospital Universitari Vall d’Hebron . Barcelona), Dr . Xavier Forns Bernhardt (Hospital Clínic of Barcelona), Dr . Javier García-Samaniego Rey (Hospital La Paz-Carlos III . Madrid), Dr . Jordi Gómez Castilla (CSIC Instituto Lopez Neyra . Granada), Dr . Manuel Romero Gómez (Hospital Universitario de Valme, Sevilla), Dr . Javier Salmeron Escobar (Hospital Universitario San Cecilio . Granada) and Dr . Marisa
García Buey (Hospital de la Princesa . Madrid) in addition to a linked clinical group Dr . José Luis Calleja (H . Puerta del Hierro, Madrid) .
• Public HBV database named CIBERHEP, owned by CIBEREHD is open to all National Health professionals willing to participate in the Project and is coordinated by Dr . M . Buti and Dr . R . Esteban (HUVH) http://hepatitis .ciberehd .org / https://www .ciberehd .org/ is completely active and has given rise to papers presented in national and international congresses . As an example, the presentation in the 49th Annual Meeting of the EASL (Poster 1211): “Efficacy of tenofovir in patients who have received prior treatment with nucleoside/nucleotide analogues and comparing them with patients who have not previously been treated (naïve)” in which 370 patients in treatment with tenofovir were included . CIBERHEP has over 1149 patients (September 2014), 25 participating centres from 9 Spanish Regions (718 have received Tenofovir; 384 have received Entecavir) .
• A HIGH-PERFORMANCE HVC SUBTYPING system based on ultradeep pyrosequencing and molecular phylogenesis has been developed and patented as the successful result of a project funded by the CDTI (Centro para el Development Tecnológico Industrial) in collaboration with Roche Diagnostics and ABL, subsidised by MINECO IDI-20110115 (Coordinated by Dr . J . I . Esteban) . In 2014 and continuing in 2015, this methodology, which has had an impact on all means of communication, is being transferred to clinical diagnostic laboratories in Spanish hospitals, and is opening the doors to Innovative Government Procurement systems on a regional and national level . This system is patented in international patent document WO2015001068 A1, and co-owners of said patent include CIBEREHD, Roche and VHIR .
• A public HCV data base named HepatiC, owned by Ciberehd, has been consolidated . An agreement with the AEEH (Asociación Española para el Study del Liver) has been signed to open Hepatic to all National Health professionals who wish to participate in the Project . The database received approval in the Official State Journal BOE-B-2011-20823, 20 June 2011, and was registered in the Agencia Española de Protección de Datos (AEPD) . It is fully operative and more than 600 patients have been entered (September 2014) .
• With respect to HBV, studies of the variability and evolution of quasispecies by means of ultradeep pyrosequencing (UDPS) are being conducted in the framework of different health research projects . Progress has been made in developing HBV genotyping and the response to antiviral treatment which can be automated and transferred to a clinical diagnostic laboratory; replication cycle regulating regions and their relationship with the severity of the hepatic disease are being studied . The variants involved in resistance to antiviral treatment and which escape the immune system are being analysed . HBV variants in the preS region of HBsAg and in the HBV and HDV input receptor, and whether or not there is a need to establish a cell culture model to study the ineffectiveness of HBV and HDV replication based on primary hepatocytes (Dr . R . Esteban, Dr . M . Buti, Dr . F . Rodriguez-Frías, Dr . J . Muntané, Dr . J . I . Esteban) .
22
CIBEREHD » Annual report 2014