Page 24 - MEMOCiberehd014-ENG

• New anti-HCV inhibitors (quercetin, etc . ) and the role of different receptors at the entry of HCV into the hepatocyte, such as clatrin and apolypoproteins b and e in cell-to-cell HCV transmission, have been characterised (Dr . L . C . Garcia-Buey, Dr . P . Majano, Dr . Ma Ángeles Muñoz Fernández (CIBERBBN), Dr . X . Forns, Dr . S . Perez del Pulgar) .
• Studies on the effect of compounds of natural extracts on in vitro NS3 inhibition activity, as well as GWAS studies in patients subjected to treatment with NS3 inhibitors have been conducted (Dr . M . Romero-Gómez, Dr . JA del Campo leading a group of 8 hospitals)
• Progress has been made in the development of new HCV treatment techniques, as in the case of the synthesis of specific HCV anti-core aptamers (Dr . C . Briones, Dr . J . García-Samaniego, Dr . A . Madejón)
• Another group of collaborative studies is related to the search for non-invasive biomarkers of the prognosis, progression and response to treatment of Chronic Hepatitis B and C (Dr . L . C . Garcia- Buey, Dr . P . Majano, Dr . J . García-Samaniego, Dr . A . Madejon, Dr . J . Salmeron, Dr . F . Abad-Santos, Dr . A . M . Aransay (CicBioGUNE (Bilbao)) .
• An example of the close collaboration between groups in Programme 2 is the publication of the paper in which it is proven that HCV replication capacity or fitness is a determining factor in the response to treatment (Dr . E . Domingo, Dr . C . Perales, Dr . J . I . Esteban, Dr . J . Quer, Dr . J . Gregori) .
• Most of the groups have participated and are actively participating in multicentre Clinical Trials with new combinations of anti-HCV direct acting antivirals
• Finally, it should be pointed out that with the use of new technologies, such as GWAS, ultradeep pyrosequencing using the 454/Roche platform and structural RNA biosensors using microarrays, have allowed increasing the number of collaborative publications in peer-review journals and opening up new collaborative lines of research .
In summary, the collaborative activity conducted in 2014 in CIBEREHD Programme 2 has allowed increasing the competitive research capacity of our network and has opened up new doors to funding which will materialise in the coming years .
24 CIBEREHD » Annual report 2014