Page 34 - MEMOCiberehd014-ENG

As regards the study of new mechanisms regulating biliary function, has been characterised the role of type P1 purinergic receptors in the termination of the ATP-dependent signal regulating bile flow in cholangiocytes and the possible implication in biliary cancer .
Functional crosstalk between the adenosine transporter CNT3 and purinergic receptors in the bi- liary epithelia . GoDoy v, banales JM, MeDina JF, Pastor-anGlaDa M. Journal of Hepatology (2014) 61(6):1337-43 .
As regards the oncogenic processes which are associated with chronic hepatopathy accompanied by cholestasis, the role of biliary acids and their interaction with macrophages in the development of inflammatory processes and the cholangiocarcinoma promoting capacity has been characterised . The role of the chemoresistance protein BCRP as a biliary acid export pump, having an important role in the barrier against these compounds, has been identified .
Important steps have been taken for the development of cancer immunotherapy, conducting the first clinical trial with immunological checkpoint inhibitors in this tumour, demonstrating in animal models the advantages of the combination of these molecules vs . monotherapy, and improving immune response stimulation systems by means of adoptive cell therapy .
Short-term intratumoral interleukin-12 expressed from an alphaviral vector is sufficient to induce an effi- cient antitumoral response against spontaneous hepatocellular carcinomas . roDriGuez-MaDoz Jr, zabala M, alFaro M, Prieto J, KraMer MG, sMerDou c. Hum Gene Ther . 2014 Feb;25(2):132-43 .
sobrevals l, Mato-berciano a, urtasun n, Mazo a, Fillat c. uPAR-controlled oncolytic adenoviruses elimi- nate cancer stem cells in human pancreatic tumors . Stem Cell Research (2014) 12(1):1-10 .
Finally, on a clinical level, research for CIBEREHD has developed and validated non-invasive criteria of hepatocellular carcinoma in the risk population . These criteria have been included in worldwide clinical practice guidelines and have recently been incorporated by the Radiological Society of North America . Trials after curative treatment or coadjuvant to locoregional treatments have been conducted . Unfortunately, the trials have not achieved any positive results . Studies not sponsored by the industry led from CIBEREHD have established clave concepts, such as the association of side effects and better therapeutic efficacy, which makes it necessary to modify the design of clinical trials according to this parameter .
Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib . reiG M, torres F, roDriGuez-loPe c, Forner a, llarch n, riMola J, Darnell a, ríos J, ayuso c, bruiX J. J hePatol. 2014 Aug;61(2):318-24 .
In the field of locoregional therapies, the antineoplastic activity profile of radioembolization has been confirmed with Yttrium 90 microspheres, the dose calculation system has been improved for increasing technique safety and the biological response to treatment, which will allow further studying synergies and prevention of complications, has been studied for the first time .
Radioembolization of hepatocellular carcinoma activates liver regeneration, induces inflammation and endothelial stress and activates coagulation . FernanDez-ros n, iñarrairaeGui M, ParaMo Ja, berasain c, ávila Ma, choPitea a, varo n, sarobe P, bilbao Ji, DoMinGuez i, D’avola D, herrero Ji, quiroGa J, Sangro B24836705 . . Liver Int . 2014 May 16 . doi: 10 .1111/liv .12592 . [Epub ahead of print] PubMed PMID:
Top-level research aimed at establishing the efficacy of early detection campaigns, supported by the AECC and the Ministry of Health, has been conducted in colorectal cancer . In this context, national studies COLONPREV and EPICOLON, which both seek to establish new strategies for the prevention of colorectal cancer in a population of intermediate and high risk, respectively, should be highlighted . The project COLONPREV is drawn up on the basis of a prospective, controlled and randomised study comparing the immunological detection of fecal occult blood, which is the approach currently recommended in Spain by the Interterritorial Board of Health, and colonoscopy . Round-one results show that both approaches allow
34 CIBEREHD » Annual report 2014