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Project 5
Project Title:
HEPATOCARCINOMA.
Lead Group: De la Mata M. Principal Investigator: De la Mata M.
OBJECTIVES:
This line seeks to improve the prognosis of patients with hepatocarcinoma by means of the identification of biomarkers capable of providing an early diagnosis of the disease, as well as rationalizing the use of sorafenib in patients in advanced stages of the disease, such that patients with progression of the disease despite said treatment can access therapies of second line and improve the expectations of survival .
ACTIVE PROJECTS:
• “Importancia de la activación del sistema inmune para eliminar células tumorales circulantes y prevenir la recidiva del hepatocarcinoma tras el trasplante hepático” (FIS PI14/01469) . Funded in FIS call for proposals (PI: Dr . Manuel de la Mata; Co-PI: Manuel Rodríguez Perálvarez) .
• Inhibition of the mTOR pathway in transplant patients due to hepatocellular carcinoma and its effect on disease recurrence . Funded in FIS call for proposals and extended (PI: Dr . Manuel de la Mata) .
ACTIVE STUDY:
“Estudio fase IV, multicéntrico, aleatorizado, doble-ciego, controlado frente a placebo, a evaluar la eficacia y seguridad de Sorafenib en pacientes con hepatocellular carcinoma avanzado con progresión radiológica” (EC11-185) . Funded by the Ministry of Health, Equality and Social Services (PI: Dr . JL Montero) .
Project 6
Project Title:
BIOMARKERS IN THE DIFFERENTIAL DIAGNOSIS OF ACUTE CELLULAR REJECTION AND THE RECURRENCE OF HEPATITIS C AFTER LIVER TRANSPLANT Lead Group: M. Navasa Principal Investigator: M. Navasa
Collaborating groups: X. Forns CIBEREHD Group: De la Mata
OBJECTIVES:
• Evaluate a panel of serological biomarkers in the differentiation between acute rejection and recurrence of hepatitis post-liver transplant .
• Study if any of the evaluated biomarkers allows predicting the response to the treatment of cellular rejection
• Determine if these biomarkers allow the early identification of patients with a serious recurrence of hepatitis C after liver transplant .
The study is in the collected sample processing phase .
32 CIBEREHD » Annual report 2014