Page 30 - MEMOCiberehd014-ENG

these complications improve with the elimination of HCV, but only if the liver damage is not too advanced .
lara J, lóPez-labraDor F, González-canDelas F, berenGuer M, KhuDyaKov ye. Computational models of liver fibrosis progression for hepatitis C virus chronic infection . BMC Bioinformatics . 2014;15 Suppl 8:S5 .
This paper is a collaborative study with the CIBER de Epidemiología y Salud Pública, and with the Center for Disease Control in the United States .
Peña-Moral JM, Pons Ja, toMe s, GuDe F, Miras M, berMeJo J, raMirez P, berenGuer M, varo e, Forteza J, Parrilla P. Acute cellular rejection versus recurrent hepatitis C after liver transplantation: Clinical and pathological features driving a rational diagnostic approach . Hepatol Res . 2015 Apr;45(4):423-31
This is a collaborative study with the group from Virgen la Arrixaca, Murcia, which validated a diagnostic algorithm for the rejection in patients with recurrent hepatitis C based on specific histological findings .
FernánDez-carrillo c, coto-llerena M, González P, cresPo G, Mensa l, caro-Pérez n, GaMbato M, navasa M, Forns X, Pérez-Del-PulGar s. IFNL4 polymorphism predicts response to hepatitis C treatment after liver transplantation . J Clin Virol . 2014 Oct;61(2):282-5 .
Mariño z, Mensa l, cresPo G, Miquel r, bruGuera M, Pérez-Del-PulGar s, bosch J, Forns X, navasa M.
Early periportal sinusoidal fibrosis is an accurate marker of accelerated HCV recurrence after liver transplantation . J Hepatol . 2014 Aug;61(2):270-7 .
cresPo G, lens s, GaMbato M, carrión Ja, Mariño z, lonDoño Mc, Miquel r, bosch J, navasa M, Forns X. Liver stiffness 1 year after transplantation predicts clinical outcomes in patients with recurrent hepatitis C . Am J Transplant . 2014 Feb;14(2):375-83
Project 3
Project title:
MULTICENTRE STUDY FOR THE VALIDATION OF BIOMARKERS OF CHOICE THAT REFLECT THE INDIVIDUAL REPONSE OF SOLID ORGAN TRANSPLANT RECIPIENTS TO IMMUNOSUPPRESSIVE TREATMENT. Lead Group: Navasa
Lead Group: M. Brunet COLLABORATING GROUPS:
CIBEREHD Groups: Álvarez, Parrilla. OBJETIVOS:
The general objective of this study consists of choosing and validating optimal pharmacodynamic biomarkers, together with pharmacokinetic parameters, which reflect the individual response to immunosuppressive treatment and are predictive of the clinical progression of solid organ transplant recipients (acute rejection, infection, toxicity) . This study has ended . The result of a multicentre study which analyses the predictive value of IFN-γ, IL-17 and IL-2 in the diagnosis of acute liver and kidney rejection was published in 2014 .
Millán o, raFael-valDivia l, san seGunDo D, boiX F, castro-Panete MJ, lóPez-hoyos M, Muro M, valero-hervás D, riMola a, navasa M, Muñoz P, Miras M, anDrés a, GuiraDo l, Pascual J, brunet M. Should IFN-γ, IL-17 and IL-2 be considered predictive biomarkers of acute rejection in liver and kidney transplant? Results of a multicentric study . Clin Immunol . 2014 Oct;154(2):141-54 .
30 CIBEREHD » Annual report 2014