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Project 2
Project title:
LIVER TRANSPLANT AND IMMUNOSUPPRESSION.
Lead Group: M. de la Mata Principal Investigator: M. de la Mata, Co-Researcher: Manuel Rodríguez Perálvarez
OBJECTIVES:
The main objective of this line is to improve expectations of survival and quality of life for patients subject to a liver transplant because since livers are a limited and highly valued resource, their performance must be optimised as much as possible .
• Validation of the REJECT test, a non-invasive method for the diagnosis of acute rejection in liver transplant. Principal Investigator: M . de la Mata, Co-Researcher: M . Rodríguez Perálvarez
Collaborating Groups: M . Berenguer . M . Navasa
• Coordination of a project within CIBEREHD to validate a predictive model of acute cellular rejection called REJECTEST based on routine clinical and analytical data . This model has recently been developed by the group led by the Dr . Manuel de la Mata in collaboration with Royal Free Hospital of United Kingdom and Hospital of Padua (Italy) (Rodríguez-Perálvarez et al . Transplant Int 2015 . At press)
COOPERATIVE PROJECTS:
• Model of donor-recipient assignment in liver transplant. Lead Group: De la Mata M, Briceño J . CIBEREHD Groups: Berenguer, Forns, Bañares, Albillos, Navasa Other groups: 7 national and international centres .
This cooperative project has been described in the following paper, which proposes the use of artificial intelligence networks for suitable donor-recipient matching:
briceño J, cruz-raMírez M, Prieto M, navasa M, ortiz De urbina J, orti r, GóMez-bravo Má, otero a, varo e, toMé s, cleMente G, bañares r, bárcena r, cuervas-Mons v, solórzano G, vinaiXa c, rubín a, colMenero J, valDivieso a, ciria r, hervás-Martínez c, De la Mata M. Use of artificial intelligence as an innovative donor-recipient matching model for liver transplantation: results from a multicenter Spanish study .J Hepatol . 2014 Nov;61(5):1020-8 .
COOPERATIVE STUDIES
Liver transplant and HCV.
Different studies led by M . Berenguer and X . Forns (collaboration) have meant important milestones in the definition of hepatitis C recurrence in liver transplant:
ble, Michel; aGuilera, victoria; rubin, ánGel; Garcia-eliz, Maria; vinaiXa, carMen; Prieto, Martin; berenGuer, Marina. Liver Transplantation, 2014 Jan;20(1): 25-34 . Improved Renal Function in Liver Transplant Recipients Treated for Hepatitis C Virus With a Sustained Virological Response and Mild Chronic Kidney Disease . This study analysed the possible impact of the eradication of HCV in one of the extrahepatic manifestations of HCV, renal dysfunction, in liver transplant patients, verifying that
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