Page 28 - MEMOCiberehd014-ENG

Programme 4 consists of the four following groups:
The projects of the Programme are described below:
Project 1
Project title:
OPERATIONAL TOLERANCE AND WITHDRAWAL OF IMMUNOSUPPRESSANT IN PATIENTS WITH LIVER TRANSPLANT. Lead Group: M. Navasa Principal Investigator: A. Sánchez-Fueyo
COLLABORATING GROUPS: CIBEREHD GROUPS: Berenguer, De la Mata, Forns, Prieto, Parrilla, Bosch International Groups: Giuseppe Tisone (Roma), Jacques Pirenne (Lovaina), Gavin Whitehouse (London), Frans Claas (Leiden) .
OBJETIVOS:
• To determine the predictive capacity of a transcriptional tolerance test based on peripheral mononuclear blood cells to identify patients who can stop using immunosuppressant .
• To establish the clinical benefits of the withdrawal of the immunosuppressant in patients identified as tolerant based on the aforementioned transcriptional test, particularly in terms of improving renal function and various cardiovascular risk factors .
• To investigate the impact that chronic HCV infection in transplant patients with hepatitis C recurrence may have on withdrawal of the immunosuppressant .
• To analyse the gene expression profile in liver tissue to even more precisely identify patients that are tolerant to the graft . .
Important results have been obtained and have been referenced in successive reports . The work conducted in 2014 explores the relationship between chronic HCV infection and the development of immune tolerance .
bohne F, lonDoño Mc, benítez c, Miquel r, Martínez-llorDella M, russo c, ortiz c, bonaccorsi-riani e, branDer c, bauer t, Protzer u, JaecKel e, taubert r, Forns X, navasa M, berenGuer M, riMola a, lozano JJ, sánchez- Fueyo a. HCV-induced immune responses influence the development of operational tolerance after liver transplantation in humans . Sci Transl Med . 2014 Jun 25;6(242) .
principal Investigator
Centre
City
Marina Berenguer
Hospital Universitario La Fe
Valencia
Manuel de la Mata
Hospital Universitario Reina Sofía
Córdoba
Miguel Navasa
Hospital Clínico y Provincial
Barcelona
Grupo vinculado: Rocío Álvarez
Hospital Virgen de la Arrixaca
Murcia
28 CIBEREHD » Annual report 2014